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USP9X [cytosol]
Stable Identifier
R-MMU-870499
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P70398
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)
USP9X [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
USP9X [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ub-specific processing proteases (Mus musculus)
USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)
USP9X [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
USP9X [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
Protein ubiquitination (Mus musculus)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Mus musculus)
UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Mus musculus)
UCHL3,USP7,USP9X [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Mus musculus)
UCHL3,USP7,USP9X [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
Protein localization (Mus musculus)
Peroxisomal protein import (Mus musculus)
USP9X binds Ub:PEX5L (Mus musculus)
USP9X [cytosol] (Mus musculus)
USP9X:Ub:PEX5L [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Mus musculus)
USP9X [cytosol] (Mus musculus)
USP9X:Ub:PEX5L [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase cycle (Mus musculus)
RHOU GTPase cycle (Mus musculus)
RHOU binds effectors at the plasma membrane (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
RHOU:GTP:RHOU effectors [plasma membrane] (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
RHOV GTPase cycle (Mus musculus)
RHOV binds effectors at the plasma membrane (Mus musculus)
RHOV effectors [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
RHOV:GTP:RHOV effectors [plasma membrane] (Mus musculus)
RHOV effectors [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)
USP9X [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
USP9X [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
USP9X [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P70398
Reference Genes
BioGPS Gene:22284
ENSEMBL:ENSMUSG00000031010
KEGG Gene (Mus musculus):22284
Monarch:22284
NCBI Gene:22284
Reference Transcript
RefSeq:NM_009481.2
Participates
as a candidate of
RHOV effectors [cytosol] (Mus musculus)
RHOU effectors [cytosol] (Mus musculus)
as an output of
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
as an input of
USP9X binds Ub:PEX5L (Mus musculus)
USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)
as a component of
USP9X:Ub:PEX5L [cytosol] (Mus musculus)
Ub-SMAD4:USP9X [cytosol] (Mus musculus)
as a member of
UCHL3,USP7,USP9X [cytosol] (Mus musculus)
Inferred From
USP9X [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_033507.2
PRO
P70398
MGI
894681
HMDB Protein
HMDBP14487
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13485 SMAD4
20
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
0.602
4
UniProt:A5PKW4 PSD1
0.571
3
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