Reactome | phospho-Jak2 [cytosol]

phospho-Jak2 [cytosol]

Stable Identifier

R-MMU-873799

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-Y1007-JAK2, Q62120

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Growth hormone receptor signaling (Mus musculus)
    - JAK2 phosphorylation (Mus musculus)
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Activated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Activated PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Activated PRLR:p(Y1007)-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
    - JAK2 phosphorylation of GHR (Mus musculus)
      - Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Activated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
    - PTP1B binds the GH receptor complex (Mus musculus)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Mus musculus)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
    - PTP1B dephosphorylates GHR (Mus musculus)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Mus musculus)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - Growth Hormone:p(Y332,487,627)-Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Mus musculus)
        
        Growth Hormone:p(Y332,487,627)-Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        p(Y332,487,627)-Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        p(Y332,487,627)-Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
    - p-STAT5A/B dissociates from the Growth Hormone receptor (Mus musculus)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:p-STAT5 [plasma membrane] (Mus musculus)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
  - Interferon Signaling (Mus musculus)
    - Interferon gamma signaling (Mus musculus)
      - Binding of STAT1 to p-IFNGR1 (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - Phosphorylation of IFNGR1 by JAK kinases (Mus musculus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - Phosphorylation of JAK2 (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - Phosphorylation of STAT1 at Ser727 (Mus musculus)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - Phosphorylation of STAT1 by JAK kinases (Mus musculus)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - Regulation of IFNG signaling (Mus musculus)
        
        SOCS-1 and SOCS-3 binds to p-JAK2 (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - Release of STAT1 dimer from active receptor unit (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - Transphosphorylation of JAK1 (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
  - Prolactin receptor signaling (Mus musculus)
    - JAK2 phosphorylation (Mus musculus)
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Activated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Activated PRLR:p(Y1007)-JAK2 dimer [plasma membrane] (Mus musculus)
        
        Activated PRLR:p(Y1007)-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
      - Activation of STAT5a/b by JAK2 (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Mus musculus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Mus musculus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - JAK2 is phosphorylated, activated (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Mus musculus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - STAT5 is recruited by JAK2 (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Mus musculus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Mus musculus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - Tyrosine kinases phosphorylate the receptor (Mus musculus)
        
        Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Mus musculus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - p-STAT5 dissociates from the receptor complex (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Mus musculus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Mus musculus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Mus musculus)
        
        IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Mus musculus)
        
        IL3RB:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
    - Interleukin-4 and Interleukin-13 signaling (Mus musculus)
      - IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Mus musculus)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Mus musculus)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - STAT1,STAT3,STAT6 bind IL13:IL13R type II (Mus musculus)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Mus musculus)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Mus musculus)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Mus musculus)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - STAT1,STAT3,STAT6 phosphorylation (Mus musculus)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Mus musculus)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Mus musculus)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Mus musculus)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Mus musculus)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        p-Y1007-JAK2,p-Y-TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - p-Y-STATs dissociate (Mus musculus)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Mus musculus)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Mus musculus)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Mus musculus)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
    - Interleukin-6 family signaling (Mus musculus)
      - Interleukin-6 signaling (Mus musculus)
        
        IL6ST is tyrosine phosphorylated (Mus musculus)
        
        IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6 receptor trimer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        JAK activation (Mus musculus)
        
        IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6 receptor trimer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        PTPN11 binds CBL (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        PTPN11 binds p-Y759-IL6ST (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        PTPN11 is phosphorylated (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Phosphorylated STATs are released (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        SOCS3 binds IL6ST (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Serine phosphorylation of STATs (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF-independent MAPK1/3 activation (Mus musculus)
      - MAPK1 (ERK2) activation (Mus musculus)
        
        MAP2K2 binds MAPK1 (Mus musculus)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - MAPK3 (ERK1) activation (Mus musculus)
        
        MAP2K1 binds MAPK3 (Mus musculus)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
        
        IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Mus musculus)
        
        Activated JAK1, JAK2, TYK2 [cytosol] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by SCF-KIT (Mus musculus)
    - Dimerization of STATs (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
    - Disassociation and translocation of STATs to the nucleus (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
    - Phosphorylation of JAK2 (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
    - Phosphorylation of STATs (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
    - Recruitment of STATs (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Mus musculus)
        
        phospho-Jak2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q62120 Jak2

Gene Names

Jak2

Chain

chain:1-1129

Reference Genes

BioGPS Gene:16452 Jak2

KEGG Gene (Mus musculus):16452 Jak2

Monarch:16452 Jak2

NCBI Gene:16452 Jak2

Reference Transcript

Participant Of

hasComponent

hasMember

Other forms of this molecule

Jak2 [cytosol]

phospho-Jak2 [cytosol]

p-12Y-Jak2 [cytosol]

p-Y1007-Jak2 [cytosol]

Jak2 [endosome lumen]

phospho-Jak2 [cytosol]

p-Jak2 [cytosol]

Inferred From

p-Y1007-JAK2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1007

Coordinate

1007

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001041642.1, NP_032439.2

ZINC - World Drugs

JAK2_MOUSE

ZINC - FDA approved

JAK2_MOUSE

ZINC - Substances

JAK2_MOUSE

ZINC target

Q62120

PRO

Q62120

MGI

96629

ZINC - Predictions - Purchasable

JAK2_MOUSE

PDB

2HDX, 4GL9

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q91ZM2 Sh2b1	2	Sh2b1 [cytosol] (R-MMU-1675482) Sh2b1 [cytosol] (R-MMU-2671856)	0.667	3
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.626	7
UniProt:P14753 Epor	3	p-8Y-Epor [plasma membrane] (R-MMU-9006275) EpoR [plasma membrane] (R-MMU-206154) phospho-Epor [plasma membrane] (R-MMU-9006274)	0.589	4
UniProt:P48356 Lepr			0.524	3
UniProt:Q5VWK5 IL23R	2	IL23R [plasma membrane] (R-HSA-447156) p-Y-IL23R [plasma membrane] (R-HSA-8950616)	0.499	2
UniProt:O35716 Socs1	2	Socs1 [cytosol] (R-MMU-204910) Socs1 [cytosol] (R-MMU-912674)	0.482	2
UniProt:P10686 Plcg1	8	phospho-Plcg1 [plasma membrane] (R-RNO-1169084) p-4Y-Plcg1 [plasma membrane] (R-RNO-9034825) Plcg1 [plasma membrane] (R-RNO-182093) Plcg1 [plasma membrane] (R-RNO-167682) p-Plcg1 [plasma membrane] (R-RNO-182042) Plcg1 [cytosol] (R-RNO-202320) phospho-Plcg1 [cytosol] (R-RNO-202357) phospho-Plcg1 [plasma membrane] (R-RNO-167679)	0.463	3

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