Dephosphorylation of Jaks by Ptps

Stable Identifier
R-MMU-877301
Type
Reaction
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Dephosphorylation of Jaks by Ptps

Protein tyrosine phosphatases (PTPs) SHP1 and SHP2 down regulate the IFNG signaling by dephosphorylating the tyrosine residues critical to the activation of JAK kinases. PTP1B interacts directly with JAK2 but not JAK1 and dephosphorylate the tyrosine Y1007 on JAK2.

Literature References
PubMed ID Title Journal Year
8943354 Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

Jiao, H, Berrada, K, Yang, W, Tabrizi, M, Platanias, LC, Yi, T

Mol Cell Biol 1996
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of Ptpn6 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created