dsDNA:AIM2:ASC cluster binds procaspase-1

Stable Identifier
R-MMU-877388
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
dsDNA:AIM2:ASC cluster binds procaspase-1
The ASC CARD domain recruits procaspase-1 leading to autoactivation, generating caspase-1.
Literature References
PubMed ID Title Journal Year
19158675 AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Horvath, G, Fitzgerald, KA, Ablasser, A, Bauernfeind, FG, Latz, E, Hornung, V, Caffrey, DR, Charrel-Dennis, M

Nature 2009
19158676 AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Wu, J, Datta, P, Alnemri, ES, Yu, JW, Fernandes-Alnemri, T

Nature 2009
Participants
Input
Output
Orthologous Events
dsDNA:AIM2:ASC cluster binds procaspase-1 (Homo sapiens)
Authored
Jupe, S  (2011-04-28)
Reviewed
Kufer, TA  (2011-04-28)
Created
Jupe, S  (2010-06-14)
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