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HMGB1 [extracellular region]
Stable Identifier
R-MMU-879382
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
P63158
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
Innate Immune System (Mus musculus)
Advanced glycosylation endproduct receptor signaling (Mus musculus)
Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Mus musculus)
TRAF6 mediated NF-kB activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
Neutrophil degranulation (Mus musculus)
Exocytosis of ficolin-rich granule lumen proteins (Mus musculus)
Ficolin-rich granule lumen proteins [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
Exocytosis of secretory granule lumen proteins (Mus musculus)
Secretory granule lumen proteins [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
HMGB1 [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:P63158
Reference Genes
BioGPS Gene:15289
ENSEMBL:ENSMUSG00000066551
KEGG:mmu:15289
Monarch:15289
NCBI Gene:15289
UCSC:P63158
Reference Transcript
RefSeq:NM_001313894.1
RefSeq:XM_003945339.3
RefSeq:NM_010439.4
Other Identifiers
10385426
10535894
1416176_at
1425048_a_at
1435324_x_at
1439463_x_at
1448235_s_at
15289
17455476
4322293
4330118
4347468
4354402
4393434
4406953
4411007
4418883
4447650
4455752
4467997
4479000
4489324
4492614
4500089
4514542
4568217
4583471
4585956
4586369
4591370
4615297
4645926
4741301
4757303
4769722
4813426
4819692
4854124
4860402
4869667
4926410
4926514
4946184
4964001
4997293
5019549
5023982
5076848
5098616
5115967
5167336
5212441
5272335
5293890
5317303
5350044
5369980
5386464
5386530
5437297
5451517
5489745
5493799
5497116
5520533
5522077
5528151
5565013
93095_at
A_55_P2002689
A_55_P2013501
A_55_P2018283
GO:0000400
GO:0000401
GO:0000402
GO:0000405
GO:0001654
GO:0001773
GO:0001786
GO:0001934
GO:0001935
GO:0002053
GO:0002250
GO:0002270
GO:0002281
GO:0002318
GO:0002376
GO:0002643
GO:0002840
GO:0003676
GO:0003677
GO:0003681
GO:0003690
GO:0003697
GO:0003723
GO:0003725
GO:0003727
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0005737
GO:0005768
GO:0005769
GO:0005793
GO:0005829
GO:0005886
GO:0005975
GO:0005980
GO:0006091
GO:0006281
GO:0006284
GO:0006310
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006914
GO:0006935
GO:0006954
GO:0007165
GO:0008097
GO:0008201
GO:0008289
GO:0008301
GO:0010508
GO:0010858
GO:0016192
GO:0030099
GO:0030154
GO:0030295
GO:0030324
GO:0030335
GO:0031410
GO:0032392
GO:0032727
GO:0032728
GO:0032731
GO:0032755
GO:0032760
GO:0034137
GO:0034145
GO:0034165
GO:0035767
GO:0042277
GO:0043005
GO:0043226
GO:0043277
GO:0045087
GO:0045089
GO:0045121
GO:0045639
GO:0045819
GO:0045931
GO:0045944
GO:0048018
GO:0048856
GO:0048870
GO:0050786
GO:0050930
GO:0051106
GO:0051384
GO:0051861
GO:0070374
GO:0071222
GO:0071639
GO:0090303
GO:0097100
GO:0097350
GO:0098542
GO:0098761
GO:0098772
GO:1901224
GO:1903672
GO:1905455
GO:2000819
ILMN_1236808
ILMN_1242911
ILMN_1245504
mMC023580
mMR027679
z11997_s_at
Participates
as a member of
Ficolin-rich granule lumen proteins [extracellular region] (Mus musculus)
Secretory granule lumen proteins [extracellular region] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
Other forms of this molecule
HMGB1 [ficolin-1-rich granule lumen]
HMGB1 [secretory granule lumen]
HMGB1 [nucleoplasm]
HC23,45-HMGB1 [extracellular region]
Inferred From
HMGB1 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_034569.1
,
NP_001300823.1
,
XP_003945388.1
ENSEMBL
ENSMUSP00000082682
,
ENSMUSP00000106131
,
ENSMUST00000093196
,
ENSMUSP00000106132
,
ENSMUST00000085546
,
ENSMUST00000110505
PRO
P63158
GlyGen
P63158
MGI
96113
PDB
5ZE1
,
5ZE0
,
5ZE2
,
5ZDZ
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01860 POU5F1 (OCT4)
1
POU5F1 [nucleoplasm]
(R-HSA-452472)
0.591
3
UniProt:Q8VIM0 Havcr2
1
Havcr2 [plasma membrane]
(R-MMU-5340387)
0.571
4
UniProt:P63002 Tle5
1
Aes [nucleoplasm]
(R-MMU-4648965)
0.558
3
UniProt:Q62440
2
Tle1 [nucleoplasm]
(R-MMU-3322369)
Tle1 [nucleoplasm]
(R-MMU-212327)
0.558
2
UniProt:P22893
2
phospho-Zfp36 [cytosol]
(R-MMU-450496)
Zfp36 [cytosol]
(R-MMU-450562)
0.558
2
UniProt:P02340 Tp53
20
TP53 [cytosol]
(R-MMU-8869337)
PolyUb-TP53 [nucleoplasm]
(R-MMU-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-MMU-2997661)
p- S18-Tp53 [nucleoplasm]
(R-MMU-9816424)
phospho-p-S15,S20-TP53 [nucleoplasm]
(R-MMU-69683)
phospho-p-S15-TP53 [nucleoplasm]
(R-MMU-69507)
TP53 [nucleoplasm]
(R-MMU-69488)
PolyUb-TP53 [cytosol]
(R-MMU-6793681)
PolyUb-TP53 [nucleoplasm]
(R-MMU-6793679)
phospho-PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-6804446)
phospho-p-S37-TP53 [nucleoplasm]
(R-MMU-3239022)
phospho-p-T55-TP53 [nucleoplasm]
(R-MMU-6805400)
phospho-p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-MMU-6805133)
phospho-p-S15,S20,S46-TP53 [nucleoplasm]
(R-MMU-6798369)
phospho-p-S15,S392-TP53 [nucleoplasm]
(R-MMU-3222015)
phospho-p-S15,S33,S46-TP53 [nucleoplasm]
(R-MMU-6805268)
phospho-p-S15,S20,S392-TP53 [nucleoplasm]
(R-MMU-6805053)
phospho-p-S315-TP53 [nucleoplasm]
(R-MMU-6805106)
phospho-Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-5628868)
phospho-Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-6805631)
0.558
2
UniProt:Q9Z2D6 Mecp2
4
phospho-Mecp2 [nucleoplasm]
(R-MMU-9022331)
phospho-Mecp2 [nucleoplasm]
(R-MMU-9022333)
Mecp2 [nucleoplasm]
(R-MMU-9005573)
Mecp2 [nucleoplasm]
(R-MMU-9005539)
0.558
2
UniProt:Q04863
2
Relb [nucleoplasm]
(R-MMU-5607656)
Relb [cytosol]
(R-MMU-5607652)
0.558
2
UniProt:P13405 Rb1
18
Rb1 [nucleoplasm]
(R-MMU-68642)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687347)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687351)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687355)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687354)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687353)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687352)
phospho-Rb1 [nucleoplasm]
(R-MMU-69226)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687357)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687356)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687335)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687334)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687339)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687336)
phospho-Rb1 [nucleoplasm]
(R-MMU-9687343)
Rb1 [cytosol]
(R-MMU-9660621)
phospho-Rb1 [nucleoplasm]
(R-MMU-188389)
Rb1 [nucleoplasm]
(R-MMU-1227910)
0.558
2
UniProt:O88597
3
Becn1 [cytosol]
(R-MMU-6782989)
phospho-Becn1 [cytosol]
(R-MMU-5682391)
Becn1 [cytosol]
(R-MMU-1632841)
0.499
3
UniProt:P06746 POLB
2
POLB [nucleoplasm]
(R-HSA-53845)
PolyUb-POLB [nucleoplasm]
(R-HSA-6783152)
0.462
2
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