Gdpd1 hydrolyzes LysoPtdCho

Stable Identifier
R-MMU-8847424
Type
Reaction [transition]
Species
Mus musculus
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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Gdpd1 hydrolyzes LysoPtdCho
The mouse enzyme Gdpd1 (Glycerophosphodiester phosphodiesterase domain-containing protein 1, also known as Gde4 - Glycerophosphodiester phosphodiesterase 4) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of LysoPtcCho (lysophosphatidylcholine) to GPCho (glycerophosphocholine) and LCFA (long chain fatty acid) (Oshima et al. 2015).
Literature References
PubMed ID Title Journal Year
25528375 New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity

Honda, A, Araki, M, Corda, D, Mariggiò, S, Yamashita, Y, Kato, N, Nagano, T, Yanaka, Noriyuki, Ohshima, N, Izumi, T, Isaji, C, Kudo, T

J. Biol. Chem. 2015
Participants
Input
Output
Catalyst Activity

lysophospholipase activity of Gdpd1 [endoplasmic reticulum membrane]

Physical Entity
Gdpd1 [endoplasmic reticulum membrane] (Mus musculus)
Activity
lysophospholipase activity (GO:0004622)
Orthologous Events
GDPD1 hydrolyzes LysoPtdCho (Homo sapiens)
Authored
D'Eustachio, P  (2015-11-28)
Reviewed
Jassal, B  (2015-11-30)
Created
D'Eustachio, P  (2015-11-30)
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