Reactome | Btbd6 [cytosol]

Btbd6 [cytosol]

Stable Identifier

R-MMU-8863208

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

BTBD6, Q8K2J9

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Mus musculus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Btbd6 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8K2J9

Gene Names

Btbd6

Reference Genes

BioGPS Gene:399566 Btbd6

ENSEMBL:ENSMUSG00000002803

ENSEMBL:ENSMUSG00000002803.15 Btbd6

KEGG Gene (Mus musculus):399566 Btbd6

Monarch:399566 Btbd6

NCBI Gene:399566 Btbd6

UCSC:Q8K2J9 Btbd6

Reference Transcript

Other Identifiers

10398929

115387_at

1435153_at

17279427

399566

4334188

4402635

4502141

4686543

4687991

5213048

5246190

5407101

GE1522022

GO:0005515

GO:0005737

GO:0005829

GO:0022008

GO:0030154

GO:0048856

ILMN_2774822

mMC023218

Participates

as a member of

BTB proteins [cytosol] (Mus musculus)

Inferred From

BTBD6 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001139372.1, NP_964008.2, XP_006516119.1

Ensembl

ENSMUSG00000002803, ENSMUSP00000002880, ENSMUSP00000152889, ENSMUST00000002880, ENSMUST00000165079, ENSMUSP00000127286, ENSMUST00000221104

PRO

Q8K2J9

MGI

3026623

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