Reactome | GSPT1 [cytosol]

GSPT1 [cytosol]

Stable Identifier

R-MMU-8865759

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q8R050

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        eRF3:GDP [cytosol] (Mus musculus)
        
        eRF3 [cytosol] (Mus musculus)
        
        GSPT1 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        eRF3:GDP [cytosol] (Mus musculus)
        
        eRF3 [cytosol] (Mus musculus)
        
        GSPT1 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        eRF3:GDP [cytosol] (Mus musculus)
        
        eRF3 [cytosol] (Mus musculus)
        
        GSPT1 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        eRF3:GDP [cytosol] (Mus musculus)
        
        eRF3 [cytosol] (Mus musculus)
        
        GSPT1 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        eRF3:GDP [cytosol] (Mus musculus)
        
        eRF3 [cytosol] (Mus musculus)
        
        GSPT1 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        eRF3:GDP [cytosol] (Mus musculus)
        
        eRF3 [cytosol] (Mus musculus)
        
        GSPT1 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        eRF3:GDP [cytosol] (Mus musculus)
        
        eRF3 [cytosol] (Mus musculus)
        
        GSPT1 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        eRF3:GDP [cytosol] (Mus musculus)
        
        eRF3 [cytosol] (Mus musculus)
        
        GSPT1 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        eRF3:GDP [cytosol] (Mus musculus)
        
        eRF3 [cytosol] (Mus musculus)
        
        GSPT1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8R050

Reference Genes

BioGPS Gene:14852

ENSEMBL:ENSMUSG00000062203

ENSEMBL:ENSMUSG00000062203.16

KEGG Gene (Mus musculus):14852

Monarch:14852

NCBI Gene:14852

UCSC:Q8R050

Reference Transcript

Other Identifiers

10437748

110389_at

110390_g_at

1426736_at

1426737_at

1452168_x_at

1455173_at

14852

17328201

17328220

4313074

4391963

4437232

4444642

4614173

4637222

4731890

4787895

4845044

4908669

4940745

4962300

5140264

5157214

5170733

5194447

5217145

5233910

5275356

5312112

5335119

5421374

5466680

93727_at

A_51_P440004

A_55_P2170963

A_65_P18160

GE33276

GO:0000166

GO:0000184

GO:0003747

GO:0003824

GO:0003924

GO:0005525

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0006415

GO:0006449

GO:0016071

GO:0016787

GO:0018444

GO:0022626

GO:0043226

GO:0045182

ILMN_1244646

ILMN_2791578

Msa.28090.0_s_at

aa409254_rc_at

mMC020776

Participates

as a member of

eRF3 [cytosol] (Mus musculus)

Inferred From

GSPT1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_666178.2, NP_001123480.1

Ensembl

ENSMUSP00000130583, ENSMUSG00000062203, ENSMUST00000167571, ENSMUST00000080030, ENSMUSP00000078940

PRO

Q8R050

MGI

1316728

PDB

2RQG, 2RQH

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