Reactome | Pacsin1 [cytosol]

Pacsin1 [cytosol]

Stable Identifier

R-MMU-8868269

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

PACSIN1, Q61644

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN1 dimer [cytosol] (Mus musculus)
        
        Pacsin1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q61644

Gene Names

Pacsin1

Reference Genes

BioGPS Gene:23969 Pacsin1

ENSEMBL:ENSMUSG00000040276

KEGG:mmu:23969 Pacsin1

Monarch:23969 Pacsin1

NCBI Gene:23969 Pacsin1

UCSC:Q61644 Pacsin1

Reference Transcript

Other Identifiers

10443201

1449380_at

1449381_a_at

17335145

23969

4375177

4378322

4480837

4550364

4590536

4735976

4832620

4861658

4875057

4876202

4923295

5054641

5084776

5151134

5223641

5261848

5330945

5359142

5374153

5379670

5447247

5546623

92949_at

A_51_P220422

A_52_P200960

A_52_P531693

A_55_P2020602

A_55_P2020607

GE119531

GO:0005515

GO:0005543

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0006897

GO:0007010

GO:0007015

GO:0007165

GO:0008092

GO:0008289

GO:0016192

GO:0030100

GO:0030137

GO:0030659

GO:0031410

GO:0032587

GO:0042802

GO:0042995

GO:0043005

GO:0043209

GO:0043226

GO:0043679

GO:0045202

GO:0045806

GO:0048471

GO:0048488

GO:0048666

GO:0048812

GO:0048856

GO:0061024

GO:0072657

GO:0072659

GO:0097320

GO:0098684

GO:0098833

GO:0098839

GO:0098978

GO:0099149

GO:1900006

ILMN_1244892

ILMN_2594837

ILMN_2644415

ILMN_3153080

X85124_s_at

mMC016528

mMC024146

mMR030826

Participates

as a component of

PACSIN1 dimer [cytosol] (Mus musculus)

Inferred From

PACSIN1 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSMUSP00000155999, ENSMUST00000045896, ENSMUSP00000044168, ENSMUST00000231669, ENSMUSG00000040276, ENSMUST00000097360, ENSMUST00000114873, ENSMUST00000232437, ENSMUSP00000110523, ENSMUSP00000156003, ENSMUSP00000094973

PRO

Q61644

GlyGen

Q61644

MGI

1345181

PDB

2X3X, 2X3W, 2X3V

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10637	5	phospho-Mapt [cytosol] (R-MMU-9836400) Mapt [cytosol] (R-MMU-9619519) Mapt [cytosol] (R-MMU-350642) Mapt [cytosol] (R-MMU-350628) Mapt [cytosol] (R-MMU-201574)	0.556	5

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