Cdk5:p25 phosphorylates lamin A

Stable Identifier
R-MMU-8868356
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Cdk5:p25 phosphorylates lamin A
In a mouse Alzheimer's disease model, nuclear fragmentation, which precedes neuronal death, is initiated by phosphorylation of nuclear lamins by p25-activated Cdk5. The Cdk5:p25 complex phosphorylates lamin A (Lmna-1) at serine residues S22 and S392, with S392 being the major Cdk5 target site (Chang et al. 2011).
Literature References
PubMed ID Title Journal Year
21389115 Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

Ghosh, S, Chang, KH, Sun, KH, Lee, HP, Smith, MA, Vincent, F, Lee, HG, Multani, PS, Gupta, R, Shah, K, de Pablo, Y

Mol. Biol. Cell 2011
Participants
Catalyst Activity

protein serine/threonine kinase activity of Cdk5:p25 [nucleoplasm]

Orthologous Events
Authored
Created
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