Cdk5:p25 phosphorylates lamin B1

Stable Identifier
R-MMU-8868383
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Cdk5:p25 phosphorylates lamin B1
In a mouse Alzheimer's disease model, nuclear fragmentation, which precedes neuronal death, is initiated by phosphorylation of nuclear lamins by p25-activated Cdk5. The Cdk5:p25 complex phosphorylates lamin B1 (Lmnb1) at serine residues S24 and S394 (Chang et al. 2011), corresponding to S23 and S393 of human LMNB1, respectively.
Literature References
PubMed ID Title Journal Year
21389115 Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

Ghosh, S, Chang, KH, Sun, KH, Lee, HP, Smith, MA, Vincent, F, Lee, HG, Multani, PS, Gupta, R, Shah, K, de Pablo, Y

Mol. Biol. Cell 2011
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Cdk5:p25 [nucleoplasm]

Physical Entity
Cdk5:p25 [nucleoplasm] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CDK5:p25 phosphorylates lamin B1 (Homo sapiens)
Authored
Shah, K  (2016-02-23)
Created
Orlic-Milacic, M  (2016-04-21)
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