Slc27a3 ligates CoA to VLCFA

Stable Identifier
R-MMU-8875095
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Slc27a3 ligates CoA to VLCFA

Acyl-coenzyme A synthetases catalyse the activation of fatty acids by thioesterification to CoA, the fundamental initial reaction in fatty acid oxidation. Members of the long chain acyl-coenzyme A synthetases (ACSVL) subfamily were originally thought to be fatty acid transport proteins (FATPs), hence their approved gene names and symbols are “solute carrier family 27 (fatty acid transporter) member x" (SLC27Ax) but their transport function has never been proven. Instead, their amino acid sequence contains two highly conserved motifs characteristic of acyl-CoA synthetases. Long-chain fatty acid transport protein 3 (Slc27a3, aka Acsvl3, Fatp3) preferentially ligates CoA-SH to very long-chain fatty acids (VLCFA) (Pei et al. 2004).

Literature References
PubMed ID Title Journal Year
15469937 Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells

Pei, Z, Fraisl, P, Berger, J, Jia, Z, Forss-Petter, S, Watkins, PA

J. Biol. Chem. 2004
Participants
Catalyst Activity
Catalyst Activity
Title
very long-chain fatty acid-CoA ligase activity of Slc27a3 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created