Reactome | Activated Src [nucleoplasm]

Activated Src [nucleoplasm]

Stable Identifier

R-MMU-8937700

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

p-Y424-Src, Neuronal proto-oncogene tyrosine-protein kinase Src, SRC_MOUSE

External Reference Information

External Reference

UniProt:P05480 Src

Gene Names

Src

Chain

initiator methionine:1, chain:2-535

Reference Genes

BioGPS Gene:20779 Src

ENSEMBL:ENSMUSG00000027646 Src

KEGG Gene (Mus musculus):20779 Src

Monarch:20779 Src

NCBI Gene:20779 Src

UCSC:P05480 Src

Reference Transcript

Other Identifiers

10477970

108711_at

1423240_at

1450918_s_at

17378721

20779

4447733

4804560

4812643

4829346

5034979

5043570

5059963

5091749

5135638

5152044

5258840

5302244

5305028

5374549

5400005

5430370

5495801

99388_at

A_52_P600547

GE33726

GO:0003674

GO:0004672

GO:0004713

GO:0005515

GO:0005524

GO:0006464

GO:0006468

GO:0008150

GO:0016301

GO:0043167

ILMN_1254757

ILMN_2638454

ILMN_2638455

ILMN_3148543

Msa.1184.0_at

mMC016824

Participates

as an input of

Runx1 binds Src (Mus musculus)

as an output of

Src phosphorylates Runx1 (Mus musculus)

as a component of

Runx1:Activated Src [nucleoplasm] (Mus musculus)

Other forms of this molecule

Src [cytosol]

phospho-Src [cytosol]

phospho-Src [plasma membrane]

Src [plasma membrane]

phospho-Src [plasma membrane]

Src [cytosol]

phospho-Src [plasma membrane]

Src [plasma membrane]

MyrG-p-Y424-Src [plasma membrane]

phospho-Src [cytosol]

Src [cytosol]

Modified Residues

Name

O4'-phospho-L-tyrosine at 424

Coordinate

424

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_033297.2, NP_001020566.1

ZINC - Substances

SRC_MOUSE

ZINC target

P05480

Ensembl

ENSMUSG00000027646, ENSMUSP00000105155, ENSMUST00000109529, ENSMUSP00000090237, ENSMUST00000092576

PRO

P05480

ZINC - Predictions - Purchasable

SRC_MOUSE

MGI

98397

PDB

6F3F

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05397 PTK2	11	p-5Y-PTK2 [cytosol] (R-HSA-5218711) pY-PTK2 [cytosol] (R-HSA-9632393) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.683	5
UniProt:P31016 Dlg4	3	Dlg4 [cytosol] (R-RNO-6794248) Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [plasma membrane] (R-RNO-9612601)	0.645	9
UniProt:P19367 HK1	4	HK1 577-672del [cytosol] (R-HSA-5621873) HK1 T680S [cytosol] (R-HSA-5621880) HK1 L529S [cytosol] (R-HSA-5621861) HK1 [cytosol] (R-HSA-70395)	0.644	8
UniProt:P35438 Grin1	3	Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.643	4
UniProt:Q01973 ROR1	2	ROR1 [plasma membrane] (R-HSA-197814) ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727)	0.602	3
UniProt:P52789 HK2	1	HK2 [cytosol] (R-HSA-70378)	0.602	4
UniProt:Q13507-3 TRPC3			0.602	4
UniProt:P05106 ITGB3	3	ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) p-T779-ITGB3 [plasma membrane] (R-HSA-432107) ITGB3 [plasma membrane] (R-HSA-57600)	0.602	5
UniProt:O70469	1	Dok2 [cytosol] (R-MMU-204823)	0.591	4
UniProt:Q00959 Grin2a	3	p-Y-Grin2a [plasma membrane] (R-RNO-9628245) Grin2a [endoplasmic reticulum membrane] (R-RNO-9609845) Grin2a [plasma membrane] (R-RNO-6794271)	0.558	5
UniProt:Q9CQV6	3	Map1lc3b [cytosol] (R-MMU-5682674) Map1lc3b [autophagosome membrane] (R-MMU-5683641) Map1lc3b [cytosol] (R-MMU-5205651)	0.528	2
UniProt:P07141	3	Csf1 [endoplasmic reticulum lumen] (R-MMU-8956778) phospho-Csf1 [endoplasmic reticulum lumen] (R-MMU-8956881) Csf1 [extracellular region] (R-MMU-9009484)	0.524	2
UniProt:P70315 Was	1	Wasp [cytosol] (R-MMU-2029026)	0.524	2
UniProt:P31750 Akt1	10	phospho-Akt1 [plasma membrane] (R-MMU-199430) p-T308,S473-Akt1 [plasma membrane] (R-MMU-1445123) p-T308,S473-Akt1 [cytosol] (R-MMU-162346) phospho-Akt1 [cytosol] (R-MMU-8848757) phospho-Akt1 [cytosol] (R-MMU-198634) phospho-Akt1 [nucleoplasm] (R-MMU-198357) Akt1 [cytosol] (R-MMU-58252) Akt1 [plasma membrane] (R-MMU-199416) phospho-Akt1 [plasma membrane] (R-MMU-377265) phospho-Akt1 [cytosol] (R-MMU-198356)	0.499	3
UniProt:P23242	6	Gja1 [Golgi membrane] (R-MMU-190649) Gja1 [endoplasmic reticulum membrane] (R-MMU-190654) Gja1 [lysosomal membrane] (R-MMU-196173) phospho-Gja1 [plasma membrane] (R-MMU-191657) Gja1 [Golgi-associated vesicle membrane] (R-MMU-190544) Gja1 [plasma membrane] (R-MMU-158058)	0.499	3
UniProt:Q63767	4	phospho-Bcar1 [cytosol] (R-RNO-5218739) phospho-Bcar1 [cytosol] (R-RNO-372645) phospho-Bcar1 [cytosol] (R-RNO-8848723) Bcar1 [cytosol] (R-RNO-201625)	0.471	2
UniProt:P35546	2	phospho-Ret [plasma membrane] (R-MMU-8854162) Ret [plasma membrane] (R-MMU-8853797)	0.463	2
UniProt:P54763 Ephb2	9	p-Ephb2 [plasma membrane] (R-MMU-3928433) phospho-Ephb2 [plasma membrane] (R-MMU-3928375) Ephb2 [plasma membrane] (R-MMU-443809) Ephb2 [extracellular region] (R-MMU-3928436) Ephb2 [plasma membrane] (R-MMU-3928386) Ephb2 [cytosol] (R-MMU-3928432) Ephb2 [plasma membrane] (R-MMU-3928394) Ephb2 [plasma membrane] (R-MMU-3928443) p-Y604,Y610-Ephb2 [plasma membrane] (R-MMU-4093312)	0.463	3

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