Src phosphorylates Runx1

Stable Identifier
R-MMU-8937738
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
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Src phosphorylates Runx1

In developing mouse megakaryocytes and T cells, Src tyrosine kinase phosphorylates Runx1 on seven tyrosine residues, three of which are located in the negative regulatory DNA binding domain (Y254, Y258 and Y260), and four in the inhibitory domain (Y375, Y378, Y379 and Y386). Src-mediated phosphorylation negatively regulates differentiation of hematopoietic progenitors. Tyrosine phosphorylated Runx1 exhibits decreased affinity for the Gata1 transcription factor and increased affinity for the SWI/SNF complex (Huang et al. 2012).

Literature References
PubMed ID Title Journal Year
22759635 A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation

Huang, H, Woo, AJ, Waldon, Z, Schindler, Y, Moran, TB, Zhu, HH, Feng, GS, Steen, H, Cantor, AB

Genes Dev. 2012
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Runx1:Activated Src [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created