Runx3:Cbfb binds the Rorc gene promoter

Stable Identifier
R-MMU-8949284
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Runx3:Cbfb binds the Rorc gene promoter

Mouse Runx3, in complex with its heterodimerization partner Cbfb, binds the promoter of the Rorc (Ror-gamma) gene, encoding nuclear retinoid-related orphan receptor-gamma. The Runx binding site in the mouse Rorc promoter, TGTGGT, is conserved in the human RORC promoter. Human RUNX3 protein can also bind the mouse Rorc promoter. Mouse Runx3 is expressed in innate lymphoid cell lineages ILC1 and ILC3, but not ILC2 (Ebihara et al. 2015).

Literature References
PubMed ID Title Journal Year
26414766 Runx3 specifies lineage commitment of innate lymphoid cells

Ebihara, T, Song, C, Ryu, SH, Plougastel-Douglas, B, Yang, L, Levanon, D, Groner, Y, Bern, MD, Stappenbeck, TS, Colonna, M, Egawa, T, Yokoyama, WM

Nat. Immunol. 2015
Participants
Orthologous Events
Authored
Reviewed
Created