Rorc gene expression is stimulated by Runx3:Cbfb

Stable Identifier
R-MMU-8949303
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Rorc gene expression is stimulated by Runx3:Cbfb

The Runx3:Cbfb heterodimer binds the Runx binding motif TGTGGT in the promoter of the mouse Rorc (Ror-gamma) gene and stimulates transcription of the Rorc transcript variant 2 (Rorc-2), also known as RORgT (RORgamma-t). Human RUNX3 can also stimulate transcription of the mouse Rorc gene. In the ILC3 lineage of innate lymphoid cells in mice, expression of the Ahr transcription factor is positively indirectly regulated by Runx3, most likely through RORgT (Ebihara et al. 2015).

Literature References
PubMed ID Title Journal Year
26414766 Runx3 specifies lineage commitment of innate lymphoid cells

Ebihara, T, Song, C, Ryu, SH, Plougastel-Douglas, B, Yang, L, Levanon, D, Groner, Y, Bern, MD, Stappenbeck, TS, Colonna, M, Egawa, T, Yokoyama, WM

Nat. Immunol. 2015
Participants
This event is regulated
Orthologous Events
Authored
Reviewed
Created