(p-Y543-Il23r,p-Y626-Il23r,p-Il23r):p-Jak2 [plasma membrane]

Stable Identifier
R-MMU-8950221
Type
Complex
Species
Mus musculus
Compartment
General

Experimental evidence in mouse shows how Tyr-542 and Tyr-626 in Murine Interleukin-23 receptor subunit (IL-23R) Are Important for SH2 Domain-dependent STAT3 Activation (PMID:23673666). Moreover mouse Tyr-416, Tyr-504, and Tyr-626 and human Tyr-397, Tyr-484, and Tyr- 611 were defined as potential SH2 domain-binding sites for binding of SHP2, STAT4, and STAT1/3, respectively. On the other hand Interleukin-23-mediated STAT3 activation does not rely on one single tyrosine motif within murine and huan IL-23R.

Literature References
PubMed ID Title Journal Year
23673666 Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor

Floss, DM, Mrotzek, S, Klöcker, T, Schröder, J, Grötzinger, J, Rose-John, S, Scheller, J

J. Biol. Chem. 2013
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