Stat3 binds to p-Y-Il23r from Il23:Il23 receptor

Stable Identifier
R-MMU-8950442
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
General
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Stat3 binds to p-Y-Il23r from Il23:Il23 receptor
Signal transducer and activator of transcription 3 (Stat3) binds Interleukin-23 receptor (Il23r), after cytokine-receptor interaction, for both canonical and non-canonical Stat3 activation (Dumoutier et al. 2009, Floss et al. 2013). This is a black box event because Stat3 binding as a consequence of Interleukin-23 stimulation has not been directly demonstrated.
Literature References
PubMed ID Title Journal Year
23673666 Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor

Grötzinger, J, Floss, DM, Scheller, J, Schröder, J, Rose-John, S, Mrotzek, S, Klöcker, T

J. Biol. Chem. 2013
19632985 New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain

de Meester, C, Dumoutier, L, Renauld, JC, Tavernier, J

J. Biol. Chem. 2009
Participants
Input
Output
Orthologous Events
STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
Authored
Duenas, C  (2017-05-12)
Reviewed
van de Vosse, E  (2017-05-12)
Created
Duenas, C  (2016-12-02)
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