Reactome: A Curated Pathway Database

Retsat reduces atROL to at-13,14-dhROL

Stable Identifier
R-MMU-8956439
Type
Reaction
Species
Mus musculus
Compartment
Summation

All-trans-retinol 13,14-reductase (Retsat) is an ER membrane-associated protein that mediates the saturation of the 13-14 double bond of all-trans-retinol (atROL) to produce all-trans-13,14-dihydroretinol (at-13,14-dhROL) (Moise et al. 2004). The product formed is a metabolite of unknown biological function. Mouse Retsat is expressed in many tissues, with the highest levels in liver, kidney and intestine. In human and mouse, RETSAT is induced during adipogenesis and is directly regulated by the transcription factor peroxisome proliferator activated receptor gamma (PPAR-gamma). Ablation of RETSAT inhibits adipogenesis but this block was not overcome by the product of RETSAT enzymatic activity. In adipose tissue, RETSAT is expressed in adipocytes but is downregulated in obesity. RETSAT could be a novel target for therapeutic intervention in metabolic disease (Schupp et al. 2009).

Literature References
PubMed ID Title Journal Year
Participants
This entity is regulated by:
Title Physical Entity Activity
all-trans-retinol 13,14-reductase activity of Retsat [endoplasmic reticulum membrane] Retsat [endoplasmic reticulum membrane] all-trans-retinol 13,14-reductase activity (0051786)
Orthologous Events