Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-App [endoplasmic reticulum lumen]
Stable Identifier
R-MMU-8957012
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
endoplasmic reticulum lumen
Synonyms
p-APP, P12023
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Post-translational protein phosphorylation (Mus musculus)
FAM20C phosphorylates FAM20C substrates (Mus musculus)
FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen] (Mus musculus)
FAM20C products [endoplasmic reticulum lumen] (Mus musculus)
phospho-App [endoplasmic reticulum lumen] (Mus musculus)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Mus musculus)
FAM20C phosphorylates FAM20C substrates (Mus musculus)
FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen] (Mus musculus)
FAM20C products [endoplasmic reticulum lumen] (Mus musculus)
phospho-App [endoplasmic reticulum lumen] (Mus musculus)
External Reference Information
External Reference
UniProt:P12023
Gene Names
App
Reference Genes
BioGPS Gene:11820 App
ENSEMBL:ENSMUSG00000022892
KEGG Gene (Mus musculus):11820 App
Monarch:11820 App
NCBI Gene:11820 App
UCSC:P12023 App
Reference Transcript
RefSeq:NM_001198823.1 App
Other Identifiers
10440491
11820
136210_at
136211_g_at
1420621_a_at
1427442_a_at
1440153_at
17331669
4327540
4349797
4384752
4418953
4427416
4466845
4532056
4567500
4574112
4592639
4707784
4714683
4780078
4795914
4848806
4950362
5018675
5019899
5090938
5095412
5160375
5192750
5387985
5413853
5504754
5566662
93063_at
A_52_P1123573
A_52_P468472
A_55_P2012201
GE42459
GO:0000003
GO:0000122
GO:0000185
GO:0000187
GO:0000278
GO:0000902
GO:0000978
GO:0000979
GO:0001664
GO:0001774
GO:0001878
GO:0001934
GO:0001967
GO:0002265
GO:0002376
GO:0003013
GO:0003674
GO:0003677
GO:0004867
GO:0005102
GO:0005109
GO:0005158
GO:0005178
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005635
GO:0005641
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005769
GO:0005773
GO:0005783
GO:0005790
GO:0005791
GO:0005794
GO:0005798
GO:0005856
GO:0005886
GO:0005905
GO:0005911
GO:0005929
GO:0005975
GO:0006091
GO:0006357
GO:0006378
GO:0006397
GO:0006412
GO:0006417
GO:0006464
GO:0006468
GO:0006629
GO:0006810
GO:0006878
GO:0006897
GO:0006915
GO:0006950
GO:0006979
GO:0007049
GO:0007155
GO:0007165
GO:0007176
GO:0007186
GO:0007189
GO:0007193
GO:0007219
GO:0007267
GO:0007399
GO:0007409
GO:0007568
GO:0007611
GO:0007612
GO:0007613
GO:0007617
GO:0007626
GO:0008021
GO:0008088
GO:0008150
GO:0008201
GO:0008203
GO:0008219
GO:0008283
GO:0008285
GO:0008306
GO:0008344
GO:0008542
GO:0009056
GO:0009058
GO:0009314
GO:0009986
GO:0009987
GO:0010288
GO:0010466
GO:0010468
GO:0010628
GO:0010629
GO:0010800
GO:0010951
GO:0010952
GO:0010971
GO:0014005
GO:0015031
GO:0016020
GO:0016021
GO:0016192
GO:0016199
GO:0016322
GO:0016358
GO:0016504
GO:0019722
GO:0019731
GO:0019732
GO:0019899
GO:0021700
GO:0022607
GO:0030134
GO:0030154
GO:0030198
GO:0030234
GO:0030414
GO:0030424
GO:0030426
GO:0030546
GO:0030705
GO:0030900
GO:0031175
GO:0031410
GO:0031594
GO:0032092
GO:0032640
GO:0032729
GO:0032731
GO:0032755
GO:0032930
GO:0032991
GO:0033130
GO:0033138
GO:0034121
GO:0034185
GO:0034330
GO:0034361
GO:0034362
GO:0034363
GO:0034364
GO:0034641
GO:0035066
GO:0035235
GO:0035253
GO:0040007
GO:0040011
GO:0040014
GO:0042056
GO:0042327
GO:0042535
GO:0042592
GO:0042802
GO:0042803
GO:0042995
GO:0043005
GO:0043065
GO:0043167
GO:0043197
GO:0043198
GO:0043204
GO:0043226
GO:0043235
GO:0043280
GO:0043393
GO:0043395
GO:0043410
GO:0043525
GO:0044281
GO:0044297
GO:0044304
GO:0045080
GO:0045087
GO:0045121
GO:0045177
GO:0045202
GO:0045429
GO:0045665
GO:0045666
GO:0045745
GO:0045821
GO:0045931
GO:0045944
GO:0046330
GO:0046872
GO:0046875
GO:0046914
GO:0046982
GO:0046983
GO:0048143
GO:0048169
GO:0048471
GO:0048669
GO:0048856
GO:0048870
GO:0050730
GO:0050786
GO:0050803
GO:0050808
GO:0050829
GO:0050830
GO:0050877
GO:0050885
GO:0050890
GO:0050918
GO:0051044
GO:0051087
GO:0051091
GO:0051092
GO:0051124
GO:0051233
GO:0051247
GO:0051260
GO:0051262
GO:0051276
GO:0051402
GO:0051425
GO:0051563
GO:0055037
GO:0055085
GO:0060291
GO:0061098
GO:0061844
GO:0061903
GO:0065003
GO:0070206
GO:0070374
GO:0070381
GO:0070555
GO:0070851
GO:0071280
GO:0071287
GO:0071320
GO:0071874
GO:0090026
GO:0090090
GO:0090647
GO:0097449
GO:0098793
GO:0098794
GO:0098815
GO:0106003
GO:0150003
GO:1900122
GO:1900181
GO:1900272
GO:1900273
GO:1901215
GO:1901216
GO:1901224
GO:1902004
GO:1902894
GO:1902949
GO:1902950
GO:1902961
GO:1903048
GO:1903223
GO:1903523
GO:1904022
GO:1904472
GO:1904591
GO:1904646
GO:1905606
GO:1905893
GO:1905896
GO:1905898
GO:1905906
GO:1905908
GO:1905945
GO:1990000
GO:1990090
GO:1990535
GO:1990761
GO:1990777
GO:1990812
GO:2000406
GO:2000463
ILMN_1226911
ILMN_1255833
ILMN_2597532
ILMN_2754314
ILMN_2791028
Msa.10643.0_s_at
Msa.27234.0_s_at
Msa.27849.0_s_at
mMC020808
mMR026902
x59379_s_at
Participant Of
hasMember
FAM20C products [endoplasmic reticulum lumen]
Other forms of this molecule
App [extracellular region]
App [extracellular region]
App [endoplasmic reticulum lumen]
App [platelet alpha granule lumen]
App [extracellular region]
App [endosome lumen]
App [cytosol]
App [trans-Golgi network membrane]
Inferred From
p-APP [endoplasmic reticulum lumen] (Homo sapiens)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_001185752.1
Target Pathogen
5b354852be737e166372e92b
Ensembl
ENSMUST00000227723
,
ENSMUSP00000005406
,
ENSMUSG00000022892
,
ENSMUST00000005406
,
ENSMUSP00000154061
PRO
P12023
MGI
88059
PDB
2YT0
,
2YSZ
,
2YT1
,
2ROZ
,
4YN0
,
5MYK
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P97318
2
Dab1 [cytosol]
(R-MMU-8855236)
phospho-Dab1 [cytosol]
(R-MMU-8855227)
0.704
3
UniProt:Q03157 APLP1
0.667
4
UniProt:O88307 SORL
0.635
3
UniProt:Q9WVI9 JIP1
0.621
3
UniProt:P14211 Calr
8
Calr [endocytic vesicle lumen]
(R-MMU-2239448)
Calreticulin [extracellular region]
(R-MMU-3221763)
Calr [extracellular region]
(R-MMU-2197641)
Calreticulin [phagocytic vesicle]
(R-MMU-1236838)
Calr [phagocytic vesicle membrane]
(R-MMU-1236879)
Calr [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-MMU-8863866)
Calr [integral component of lumenal side of endoplasmic reticulum membrane]
(R-MMU-985502)
Calr [endoplasmic reticulum lumen]
(R-MMU-195905)
0.621
4
UniProt:Q06335
4
Aplp2 [platelet alpha granule membrane]
(R-MMU-8848898)
Aplp2 [plasma membrane]
(R-MMU-8848902)
phospho-Aplp2 [endoplasmic reticulum lumen]
(R-MMU-8956977)
Aplp2 [endoplasmic reticulum lumen]
(R-MMU-8956784)
0.609
3
UniProt:Q9EPL2 CSTN1
0.602
3
UniProt:Q9WVI9-1 MAPK8IP1
0.576
3
UniProt:P98084 APBA2
0.564
2
UniProt:Q6PHU5
2
Sort1 [cytoplasmic vesicle membrane]
(R-MMU-434221)
Sort1 [Golgi membrane]
(R-MMU-434332)
0.556
3
UniProt:Q9QZS3 Numb
2
Numb [plasma membrane]
(R-MMU-443595)
Numb [plasma membrane]
(R-MMU-2077469)
0.524
2
UniProt:Q61477 NBL1
0.524
2
UniProt:Q9UQF2 JIP1
0.508
2
UniProt:Q9QXJ1
1
Apbb1 [nucleoplasm]
(R-MMU-5683987)
0.508
2
UniProt:Q62108 Dlg4
3
Dlg4 [endocytic vesicle membrane]
(R-MMU-416847)
SAP-90 [plasma membrane]
(R-MMU-443606)
Dlg4 [cytosol]
(R-MMU-6794267)
0.499
4
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text