G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(i) subunit alpha (Gnai) can bind directly to proto-oncogene tyrosine-protein kinase Src (Src) in vitro and in vivo. This binding results in autophosphorylation of Src and subsequently its activation. Physiologically, the Src family have implications in cell growth and cancer.
Ma, YC, Huang, J, Ali, S, Lowry, W, Huang, XY
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