Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1 binds Grb2

Stable Identifier
R-MMU-8983356
Type
Reaction [omitted]
Species
Mus musculus
Compartment
Synonyms
Grb2 binds to the Il15ra:Il15:Il2rb:Jak1:Il2rg:p-Jak3:p-Y-Shc1 complex
General
SVG |   | PPTX  | SBGN
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1 binds Grb2

GRB2 is recruited by phosphorylated SHC1 in the IL15 receptor complex (Zambricki et al. 2005, Gadina et al. 2000), as it is in the Interleukin-2 receptor complex (Li et al. 1994, Bennett et al. 1994).More in detail, human and mouse IL15 have 70.2% amino acid sequence similarity and exhibit similar trans-presentation mechanism, signal transduction machinery and biological activities. Similarly, human IL15 shows cross-reactivity with mouse cells and it was demonstrated that human and mouse IL15 showed similar responses in mouse models (Stoklasek et al. 2006) (Patidar et al. data not published).

Literature References
PubMed ID Title Journal Year
9199344 Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes

Harmer, SL, DeFranco, AL

Mol Cell Biol 1997
Participants
Orthologous Events
Authored
Reviewed
Created