Nck2 binds to Robo1,(Robo2)

Stable Identifier
R-MMU-8985822
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Nck2 binds to Robo1,(Robo2)

In mouse brain, Robo1 and/or Robo2, activated by Slit1 binding, recruit Nck2. Robo1 and Robo2 can also bind to Nck1, but only Nck2 is implicated in Slit1-induced cortical dendrite branching. The interaction between ROBO and NCK proteins involves the three SH3 domains of Nck and the PxxP-rich region between CC2 and CC3 motifs in the cytoplasmic domain of Robo (Round and Sun 2011).

Literature References
PubMed ID Title Journal Year
21600986 The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology

Round, JE, Sun, H

Mol. Cell. Neurosci. 2011
Participants
Orthologous Events
Authored
Reviewed
Created