Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2

Stable Identifier
R-MMU-9007126
Type
Reaction [omitted]
Species
Mus musculus
Compartment
Synonyms
Gab2 binds to the Il15ra:Il15:Il2rb:JAK1:Il2rg:p-Jak3:p-Y-Shc1:Grb2 complex
General
SVG |   | PPTX  | SBGN
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2

Grb2 associated binding protein 2 (Gab2) is believed to bind and be phosphorylated in response to Interleukin-2 (Il2) and Interleukin-15 (Il15) stimulation. Its phosphorylation is greatly diminished by mutation of the site in the Interleukin-2 Receptor beta chain (Y338F) (Il2rb) that recruits SHC transforming protein 1 (Shc1) (Gadina et al.2000, Wöhrle et al.2009, Gesbert et al. 1998, Brockdorff et al. 2001).
Gab2 is a phosphoprotein that is suggested to associates with PI3kinase, Growth factor receptor-bound protein 2 (Grb2) and Tyrosine protein phosphatase non-receptor type 11 (Ptpn11 or Shp2) in T and Natural Killer (NK) cells (Gu et al. 2000).
This is a black box event because Gab2 binding is inferred from Il15 stimulation of Gab2 phosphorylation (Brockdorff et al. 2001).

Literature References
PubMed ID Title Journal Year
10849428 The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines

Gadina, M, Sudarshan, C, Visconti, R, Zhou, YJ, Gu, H, Neel, BG, O'Shea, JJ

J. Biol. Chem. 2000
9660791 A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes

Gesbert, F, Guenzi, C, Bertoglio, J

J. Biol. Chem. 1998
19523893 How to Grb2 a Gab

Wöhrle, FU, Daly, RJ, Brummer, T

Structure 2009
Participants
Orthologous Events
Authored
Reviewed
Created
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