Grb2 associated binding protein 2 (Gab2) is believed to bind and be phosphorylated in response to Interleukin-2 (Il2) and Interleukin-15 (Il15) stimulation. Its phosphorylation is greatly diminished by mutation of the site in the Interleukin-2 Receptor beta chain (Y338F) (Il2rb) that recruits SHC transforming protein 1 (Shc1) (Gadina et al.2000, Wöhrle et al.2009, Gesbert et al. 1998, Brockdorff et al. 2001).
Gab2 is a phosphoprotein that is suggested to associates with PI3kinase, Growth factor receptor-bound protein 2 (Grb2) and Tyrosine protein phosphatase non-receptor type 11 (Ptpn11 or Shp2) in T and Natural Killer (NK) cells (Gu et al. 2000).
This is a black box event because Gab2 binding is inferred from Il15 stimulation of Gab2 phosphorylation (Brockdorff et al. 2001).