Fbxw7 polyubiquitinates Runx2

Stable Identifier
R-MMU-9008715
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
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Fbxw7 polyubiquitinates Runx2

In mouse cells, the E3 ubiquitin ligase Fbxw7alpha, a component of an SCF complex, polyubiquitinates Runx2 in the presence of Gsk3b (Kumar et al. 2015).

Literature References
PubMed ID Title Journal Year
26542806 E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation

Kumar, Y, Kapoor, I, Khan, K, Thacker, G, Khan, MP, Shukla, N, Kanaujiya, JK, Sanyal, S, Chattopadhyay, N, Trivedi, AK

J. Biol. Chem. 2015
Participants
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of Fbxw7alpha:Skp1:Cul1:Rbx1:p-3S-Runx2:Gsk3b [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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