Proteasome degrades polyubiquitinated Runx2

Stable Identifier
R-MMU-9008717
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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Proteasome degrades polyubiquitinated Runx2

In mouse cells, Runx2 polyubiquitinated by Fbxw7alpha is degraded by the proteasome (Kumar et al. 2015).

Literature References
PubMed ID Title Journal Year
26542806 E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation

Kumar, Y, Kapoor, I, Khan, K, Thacker, G, Khan, MP, Shukla, N, Kanaujiya, JK, Sanyal, S, Chattopadhyay, N, Trivedi, AK

J. Biol. Chem. 2015
Participants
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of Proteasome [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created