Runx2 gene expression from proximal (P2) promoter is stimulated by Runx2-P2 and inhibited by DEXA:Nr3c1

Stable Identifier
R-MMU-9009102
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
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Runx2 gene expression from proximal (P2) promoter is stimulated by Runx2-P2 and inhibited by DEXA:Nr3c1
Mouse Runx2 gene transcription from the proximal P2 promoter is autoactivated by binding of Runx2-P2 isoform to Runx2 response elements in the P2 promoter (Ducy et al. 1999). Runx2-P2 transcription is inhibited by binding of the glucocorticoid receptor (Nr3c1), activated by dexamethasone (DEXA), to a glucocorticoid receptor response element (GRE) in the Runx2 P2 promoter (Zhang et al. 2012).
Literature References
PubMed ID Title Journal Year
22422618 Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis

Huang, HY, Guo, L, He, Q, Liu, Y, Qian, SW, Ma, CG, Zhang, YY, Tang, QQ, Li, X

Mol. Endocrinol. 2012
10215629 A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

Geoffroy, V, Priemel, M, Karsenty, G, Starbuck, M, Ducy, P, Pinero, G, Amling, M, Shen, J

Genes Dev. 1999
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Nr3c1:DEXA:Runx2 gene [nucleoplasm] (Mus musculus)
Active Unit
Nr3c1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
Positively by
Regulator
Runx2-P2:Cbfb:Runx2 gene [nucleoplasm] (Mus musculus)
Active Unit
Runx2-P2:Cbfb [nucleoplasm]
Orthologous Events
RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-15)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-15)
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