Smurf1 polyubiquitinates Runx2

Stable Identifier
R-MMU-9009440
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Smurf1 polyubiquitinates Runx2
Recombinant mouse Smurf1 polyubiquitinates recombinant mouse Runx2 (Zhao et al. 2003).
Literature References
PubMed ID Title Journal Year
12738770 E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation

Oyajobi, BO, Qiao, M, Zhao, M, Mundy, GR, Chen, D

J. Biol. Chem. 2003
Participants
Input
Output
Catalyst Activity

ubiquitin protein ligase activity of Runx2:Smurf1 [cytosol]

Physical Entity
Runx2:Smurf1 [cytosol] (Mus musculus)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
SMURF1 polyubiquitinates RUNX2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-17)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-17)
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