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Il2rb and Il2rg are phosphorylated
Stable Identifier
R-MMU-9009867
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol
,
plasma membrane
,
extracellular region
ReviewStatus
5/5
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Interleukin-2 receptor subunit beta (IL2RB, IL2Rβ) and Cytokine receptor common subunit gamma (IL2RG, IL2Rγ) is tyrosine phosphorylated after Interleukin-15 (IL15) / IL15 receptor complex interaction (Adunyah et al. 1997, Zambricki et al. 2005). More in detail, human and mouse IL15 have 70.2% amino acid sequence similarity and exhibit similar trans-presentation mechanism, signal transduction machinery and biological activities. Similarly, human IL15 shows cross-reactivity with mouse cells and it was demonstrated that human and mouse IL15 showed similar responses in mouse models (Stoklasek et al. 2006) (Patidar et al. data not published). This is a black box event because more evidence to support this reaction is needed.
Literature References
PubMed ID
Title
Journal
Year
26152718
Interleukin-2 Receptor β Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules
Kirken, RA
,
Ruiz-Medina, BE
,
Ross, JA
J. Biol. Chem.
2015
9126349
Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15
Cooper, RS
,
Adunyah, SE
,
Wheeler, BJ
Biochem. Biophys. Res. Commun.
1997
Participants
Input
x 2
ATP [cytosol]
Il15:Il15ra:Il2rb:Il2rg:p-Y-Jak1:p-Y-Jak3 [plasma membrane]
(Mus musculus)
Output
x 2
ADP [cytosol]
Il15:Il15ra:p-Y-Il2rb:p-Y-Il2rg:p-Y-Jak1:p-Y-Jak3 [plasma membrane]
(Mus musculus)
Orthologous Events
IL2RB and IL2RG are phosphorylated (Homo sapiens)
Authored
Duenas, C (2017-08-07)
Reviewed
Patidar, M (2017-08-07)
Created
Duenas, C (2017-06-23)
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