Mouse Rbpj, a component of the Notch3 coactivator complex, binds to Rbpj response elements in the promoter of the mouse Heyl gene (Geimer Le Lay et al. 2014). Transcription from the human HEYL gene is stimulated by mouse Notch3 (Maier and Gessler 2000). Heyl gene expression overlaps with Notch3 expression in mouse vascular smooth muscle cells and mouse thymus (Leimeister et al. 2000). It can therefore be concluded that the Notch3 coactivator complex binds the promoter of the Heyl gene.
Maier, MM, Gessler, M
Leimeister, C, Schumacher, N, Steidl, C, Gessler, M
Geimer Le Lay, AS, Oravecz, A, Mastio, J, Jung, C, Marchal, P, Ebel, C, Dembélé, D, Jost, B, Le Gras, S, Thibault, C, Borggrefe, T, Kastner, P, Chan, S
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