Insulin secretory granules dock at the plasma membrane

Stable Identifier
Reaction [omitted]
Mus musculus
SVG |   | PPTX  | SBGN
Insulin secretory granules dock at the plasma membrane

Insulin-containing secretory granules are bound to Myosin Va via Rab27a in a complex of uncertain composition. Mysosin Va moves along the cortical actin network (actin at the periphery of the cytoplasm), carrying the granules to the inner surface of the plasma membrane.

Literature References
PubMed ID Title Journal Year
22993210 MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway

Brozzi, F, Lajus, S, Diraison, F, Rajatileka, S, Hayward, K, Regazzi, R, Molnár, E, Váradi, A

Mol. Biol. Cell 2012
18801842 Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic beta-cells

Merrins, MJ, Stuenkel, EL

J Physiol 2008
11865063 The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules

Yi, Z, Yokota, H, Torii, S, Aoki, T, Hosaka, M, Zhao, S, Takata, K, Takeuchi, T, Izumi, T

Mol Cell Biol 2002
17827149 MyRIP anchors protein kinase A to the exocyst complex

Goehring, AS, Pedroja, BS, Hinke, SA, Langeberg, LK, Scott, JD

J Biol Chem 2007
15690086 Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation

Kasai, K, Ohara-Imaizumi, M, Takahashi, N, Mizutani, S, Zhao, S, Kikuta, T, Kasai, H, Nagamatsu, S, Gomi, H, Izumi, T

J Clin Invest 2005
16714477 Insulin vesicle release: walk, kiss, pause ... then run

Rutter, GA, Hill, EV

Physiology (Bethesda) 2006
Catalyst Activity
Catalyst Activity
microfilament motor activity of Myo5a [cytosol]
Physical Entity
Orthologous Events