Notch1 gene expression is inhibited by Mecp2

Stable Identifier
R-MMU-9023376
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Notch1 gene expression is inhibited by Mecp2
Increased occupancy of the mouse Notch1 gene promoter by mouse Mecp2 correlates with decreased transcription of Notch1. Mecp2 therefore inhibits Notch1 transcription. Increased occupancy of the Notch1 promoter by Mecp2 also results in decreased expression of Notch targets Hes3 and Hes5 (Li et al. 2014)
Literature References
PubMed ID Title Journal Year
25420914 Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway

Zhong, X, Jin, P, Chau, KF, Masliah, J, Kong, G, Chi, J, Santistevan, NJ, Kadakia, M, Zhang, J, Guo, W, Li, H, Li, X, Chang, Q, Zhao, X

Nat Commun 2014
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Mecp2:Notch1 gene [nucleoplasm] (Mus musculus)
Active Unit
Mecp2 [nucleoplasm]
Orthologous Events
NOTCH1 gene expression is inhibited by MECP2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-27)
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