Reactome | Pik3ca [cytosol]

Pik3ca [cytosol]

Stable Identifier

R-MMU-9027214

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, PK3CA_MOUSE

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - RET signaling (Mus musculus)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Regulation of T cell activation by CD28 family (Mus musculus)
    - Co-stimulation by CD28 (Mus musculus)
      - CD28 dependent PI3K/Akt signaling (Mus musculus)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        PI3K binds CD28 (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
    - Co-stimulation by ICOS (Mus musculus)
      - PI3K binds ICOS (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        ICOS:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
  - TCR signaling (Mus musculus)
    - Downstream TCR signaling (Mus musculus)
      - PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)
        
        PI3K bound to TRAT [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
      - Recruitment of PI3K to plasma membrane (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        PI3K bound to TRAT [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
- Cytokine Signaling in Immune system (Mus musculus)
  - FLT3 Signaling (Mus musculus)
    - Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Mus musculus)
      - Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
      - Pik3ca [cytosol] (Mus musculus)
    - Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Mus musculus)
      - Pik3ca [cytosol] (Mus musculus)
      - active FLT3:p-Y GRB10:PI3K [plasma membrane] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-2 family signaling (Mus musculus)
      - Interleukin receptor SHC signaling (Mus musculus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
      - 14-3-3 zeta binding allows recruitment of PI3K (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
      - Interleukin receptor SHC signaling (Mus musculus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
      - Regulation of signaling by CBL (Mus musculus)
        
        CBL ubiquitinates PI3K (Mus musculus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        K63polyUb-PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Mus musculus)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K alpha [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
- Innate Immune System (Mus musculus)
  - DAP12 interactions (Mus musculus)
    - DAP12 signaling (Mus musculus)
      - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
      - p85 regulatory unit of PI3K binds p-6Y-SYK (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
  - Fc epsilon receptor (FCERI) signaling (Mus musculus)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Mus musculus)
      - PI3K associates with phosphorylated GAB2 (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
    - Role of phospholipids in phagocytosis (Mus musculus)
      - PI3K binds to p-6Y-SYK (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
      - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3ca [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P42337 Pik3ca

Gene Names

Pik3ca

Chain

chain:1-1068

Reference Genes

BioGPS Gene:18706 Pik3ca

KEGG:mmu:18706 Pik3ca

Monarch:18706 Pik3ca

NCBI Gene:18706 Pik3ca

UCSC:P42337 Pik3ca

Reference Transcript

Other Identifiers

104461_at

10491331

105294_at

107411_at

1423144_at

1429434_at

1429435_x_at

1440054_at

1453134_at

1460326_at

17396677

18706

4309901

4316895

4320285

4338378

4355475

4367322

4382560

4439253

4549024

4581965

4625194

4657985

4681028

4709761

4786729

4803381

4835203

4969416

5031753

5042014

5051238

5092973

5154725

5200497

5320537

5351640

5352161

5355209

5411587

5485642

5595387

92452_at

A_52_P265002

A_52_P577116

A_65_P09318

GE34203

GO:0001525

GO:0001889

GO:0001932

GO:0003012

GO:0003824

GO:0004674

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005942

GO:0005943

GO:0005944

GO:0005975

GO:0006006

GO:0006325

GO:0006629

GO:0006909

GO:0007010

GO:0008286

GO:0010468

GO:0010629

GO:0014704

GO:0014823

GO:0014870

GO:0016192

GO:0016301

GO:0016303

GO:0016740

GO:0030027

GO:0030036

GO:0030295

GO:0030835

GO:0032869

GO:0035005

GO:0035994

GO:0036092

GO:0038084

GO:0038203

GO:0040014

GO:0043201

GO:0043457

GO:0043491

GO:0043524

GO:0043560

GO:0046854

GO:0046934

GO:0048009

GO:0048015

GO:0048661

GO:0048856

GO:0051897

GO:0055119

GO:0060612

GO:0071333

GO:0071464

GO:0071548

GO:0086003

GO:0097009

GO:0098772

GO:0106310

GO:0110053

GO:0140096

GO:0141068

GO:1903544

GO:1905477

GO:2000270

GO:2000811

ILMN_1234800

ILMN_2825201

Msa.241.0_at

Msa.241.0_g_at

aa420333_rc_at

mMC021854

Participates

as a component of

as an input of

as a member of

PI3K-catalytic subunit [cytosol] (Mus musculus)

Inferred From

PIK3CA [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_032865.2, XP_006535472.1, XP_006535473.1

ZINC - Investigational

PK3CA_MOUSE

ENSEMBL

ENSMUST00000108243, ENSMUSP00000029201, ENSMUSP00000103878, ENSMUST00000029201

ZINC - Substances

PK3CA_MOUSE

ZINC target

P42337

PRO

P42337

MGI

1206581

ZINC - Predictions - Purchasable

PK3CA_MOUSE

PDB

4A55

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.589	3
UniProt:P26450 Pik3r1	5	p-Y-Pik3r1 [cytosol] (R-MMU-9680631) Pik3r1 [cytosol] (R-MMU-3080572) Pi3k-p85 alpha [cytosol] (R-MMU-1295777) Pik3r1 [cytosol] (R-MMU-74789) Pik3r1 [plasma membrane] (R-MMU-198365)	0.573	7
UniProt:P41241	2	CSK [plasma membrane] (R-MMU-180499) CSK [cytosol] (R-MMU-203776)	0.499	2

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