Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1 binds Shc1

Stable Identifier
R-MMU-9027266
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1 binds Shc1
After stimulation by Epo, Crkl associates with Epor, is phosphorylated, and binds Shc1 (Miura et al. 1994, Chin et al. 1997).
Literature References
PubMed ID Title Journal Year
7961995 Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor

Ihle, JN, Miura, Y, Miura, O, Aoki, N

J. Biol. Chem. 1994
9344843 Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells

Yamamoto, K, Chin, H, Kamiyama, R, Arai, A, Miura, O, Saito, T, Miyasaka, N

Biochem. Biophys. Res. Commun. 1997
Participants
Input
Output
Orthologous Events
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 (Homo sapiens)
Authored
May, B  (2017-10-21)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-10-29)
Cite Us!