Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k

Stable Identifier
R-MMU-9027268
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k
Phosphatidylinositol 4,5-bisphosphate 3-kinase (Pi3k) directly binds phosphotyrosine-479 in the cytosolic domain of Epor (Damen et al. 1993, He et al. 1993, Miura et al. 1994, Damen et al. 1995, Klingmuller et al. 1997).
Literature References
PubMed ID Title Journal Year
7559499 Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity

Jiao, H, Cutler, RL, Krystal, G, Yi, T, Damen, JE

J. Biol. Chem. 1995
7685197 Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor

Puil, L, Mui, AL, Krystal, G, Damen, JE, Pawson, T

Blood 1993
9096338 Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors

Lodish, HF, Duckworth, BC, Wu, H, Toker, A, Cantley, LC, Klingmüller, U, Hsiao, JG

Proc. Natl. Acad. Sci. U.S.A. 1997
8276859 Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor

Ihle, JN, Miura, O, Aoki, N, Nakamura, N

J. Biol. Chem. 1994
7505116 Association of the p85 regulatory subunit of phosphatidylinositol 3-kinase with an essential erythropoietin receptor subdomain

He, TC, Wojchowski, DM, Waterfield, MD, Jiang, N, Zhuang, H

Blood 1993
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Orthologous Events
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