Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Crkl:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 mediates exchange of GDP for GTP bound to Ras

Stable Identifier
R-MMU-9029152
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Crkl:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 mediates exchange of GDP for GTP bound to Ras
Sos1 and phospho-Vav1 bound to Grb2 in a complex with the activated Epor catalyze the exchange of GDP for GTP bound to Ras proteins, yielding Ra:GTP. Ras:GTP then activates Raf1, Erk1 and Erk2 (Todokoro et al. 1994). Epo is observed to activate Kras, Nras, and Hras (Zhang and Lodish 2005). Kras appears to be especially important for erythropoiesis since deletion of Kras causes anemia (Khalaf et al. 2005, Zhang and Lodish 2005, Zhang and Lodish 2007).
Literature References
PubMed ID Title Journal Year
7524495 Activation of mitogen-activated protein kinase cascade through erythropoietin receptor

Nishida, E, Sugiyama, M, Todokoro, K, Nakaya, K

Biochem. Biophys. Res. Commun. 1994
16203968 Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo

Lodish, HF, Zhang, J

Proc. Natl. Acad. Sci. U.S.A. 2005
17721087 Endogenous K-ras signaling in erythroid differentiation

Lodish, HF, Zhang, J

Cell Cycle 2007
15644420 K-Ras is essential for normal fetal liver erythropoiesis

Kapur, R, Orazi, A, Ingram, DA, White, H, Wenning, MJ, Khalaf, WF

Blood 2005
Participants
Input
Output
Catalyst Activity

guanyl-nucleotide exchange factor activity of Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 [plasma membrane]

Physical Entity
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 [plasma membrane] (Mus musculus)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)
Authored
May, B  (2017-11-11)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-11-14)
Cite Us!