Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Crkl:Rapgef1

Stable Identifier
R-MMU-9030346
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Crkl:Rapgef1
Crkl, in a constitutive complex with Rapgef1 (C3G, a nucleotide exchange factor for Rap1), binds the cytoplasmic domain of phosphorylated Epor (Chin et al. 1997).
Literature References
PubMed ID Title Journal Year
9344843 Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells

Yamamoto, K, Chin, H, Kamiyama, R, Arai, A, Miura, O, Saito, T, Miyasaka, N

Biochem. Biophys. Res. Commun. 1997
Participants
Input
Output
Orthologous Events
EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 (Homo sapiens)
Authored
May, B  (2017-11-27)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-11-27)
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