Reactome | p-Y-Frs2 [cytosol]

p-Y-Frs2 [cytosol]

Stable Identifier

R-MMU-9031970

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by NTRKs (Mus musculus)
    - Signaling by NTRK2 (TRKB) (Mus musculus)
      - Activated NTRK2 signals through FRS2 and FRS3 (Mus musculus)
        
        NTRK2-phosphorylated FRS2 binds GRB2 (Mus musculus)
        
        BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Mus musculus)
        
        p-Y-Frs2 [cytosol] (Mus musculus)
        
        BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
        
        BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Mus musculus)
        
        p-Y-Frs2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8C180 Frs2

Gene Names

Frs2, Frs2a

Chain

initiator methionine:1, chain:2-508

Reference Genes

BioGPS Gene:327826 Frs2

ENSEMBL:ENSMUSG00000020170 Frs2

KEGG Gene (Mus musculus):327826 Frs2

Monarch:327826 Frs2

NCBI Gene:327826 Frs2

UCSC:Q8C180 Frs2

Reference Transcript

RefSeq:NM_177798.3 Frs2

Other Identifiers

10372618

115218_at

1437891_at

17245188

327826

4341790

4348189

4428139

4477674

4587272

4628652

4738598

4755262

4794121

4814497

4878800

4997747

5006977

5007095

5351947

5380057

5410462

5410800

5604305

A_51_P413991

A_52_P105138

A_52_P105147

GE1502889

ILMN_1221488

ILMN_1226775

ILMN_2993711

mMC016758

Participates

as a component of

Other forms of this molecule

Frs2 [cytosol]

phospho-Frs2 [cytosol]

phospho-Frs2 [plasma membrane]

Frs2 [plasma membrane]

phospho-Frs2 [plasma membrane]

Inferred From

p-Y-FRS2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_808466.1

Ensembl

ENSMUSG00000020170, ENSMUST00000020381, ENSMUSP00000020381

PRO

Q8C180

MGI

1100860

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60631 Grb2	3	Grb2 [plasma membrane] (R-MMU-202993) Grb2 [cytosol] (R-MMU-74686) Grb2 [cytosol] (R-MMU-443287)	0.527	5

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