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phospho-p-Y1054,Y1055-TYK2 [cytosol]
Stable Identifier
R-MMU-909682
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q9R117
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Interferon alpha/beta signaling (Mus musculus)
Activation of JAK kinases (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Mus musculus)
p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
Formation of p-STAT1 homodimer (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Mus musculus)
p-STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
Phosphorylation of INFAR1 by TYK2 (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
Phosphorylation of STAT2 (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Mus musculus)
STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Mus musculus)
p-STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
Recruitment of STAT2 to p-IFNAR1 (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Mus musculus)
STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
Regulation of IFNA/IFNB signaling (Mus musculus)
Dephosphorylation of STAT1 by SHP2 (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] (Mus musculus)
p-STAT2:STAT1:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Mus musculus)
p-STAT2:p-STAT1:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
Dephosphorylation of TYK2 by PTP1B (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
Release of p-STAT2:p-STAT1 dimer (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Mus musculus)
p-STAT2:p-STAT1:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
phospho-p-Y1054,Y1055-TYK2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9R117 Tyk2
Gene Names
Tyk2
Chain
chain:1-1184
Reference Genes
BioGPS Gene:54721 Tyk2
ENSEMBL:ENSMUSG00000032175.12 Tyk2
KEGG Gene (Mus musculus):54721 Tyk2
Monarch:54721 Tyk2
NCBI Gene:54721 Tyk2
UCSC:Q9R117 Tyk2
Reference Transcript
RefSeq:NM_018793.2 Tyk2
RefSeq:XM_011242579.2 Tyk2
Other Identifiers
10591446
115736_at
1417306_at
17524620
4316789
4375044
4448500
4462039
4498605
4572329
4616938
4646678
4653017
4665788
4791276
4795496
4796531
4899877
4923368
4959927
5083845
5090639
5099449
5233350
5294124
5298785
5321568
5407628
5455516
54721
5484947
5497525
5511803
5581439
97573_at
A_51_P466824
GE37303
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005131
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006468
GO:0006955
GO:0007155
GO:0007259
GO:0008283
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0023052
GO:0030154
GO:0031702
GO:0032729
GO:0032740
GO:0032819
GO:0035556
GO:0035722
GO:0036211
GO:0042022
GO:0042102
GO:0043226
GO:0046427
GO:0051142
GO:0060333
GO:0060337
GO:0060397
GO:0072536
GO:0098542
GO:0140096
GO:1900182
GO:2000318
ILMN_2455699
ILMN_2455701
ILMN_2496712
ILMN_2848018
Msa.18847.0_s_at
mMC016165
mMC023331
Participates
as a component of
p-STAT2:STAT1:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Mus musculus)
IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
p-STAT2:p-STAT1:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
p-STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Mus musculus)
Other forms of this molecule
p-Y-Tyk2 [cytosol]
p-Tyk2 [cytosol]
phospho-p-TYK2 [cytosol]
phospho-p-Y-TYK2 [cytosol]
Tyk2 [cytosol]
TYK2 [cytosol]
phospho-p-Y1054-TYK2 [cytosol]
Inferred From
p-Y1054,Y1055-TYK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1055 (in Homo sapiens)
Coordinate
1055
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1054 (in Homo sapiens)
Coordinate
1054
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_011240881.1
,
NP_061263.2
IntEnz
2.7.10.2
ZINC - Substances
TYK2_MOUSE
ZINC target
Q9R117
Ensembl
ENSMUSG00000032175
,
ENSMUSP00000150214
,
ENSMUST00000214454
PRO
Q9R117
ZINC - Predictions - Purchasable
TYK2_MOUSE
MGI
1929470
PDB
4E20
,
4E1Z
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