As sections of the axial elements form, the telomeres migrate to one site on the inner nuclear membrane to form the telomere bouquet (Scherthan et al. 1996). A current model shows the synaptonemal complex interacting with Sun1 and Sun2, which span the inner membrane and bind Nesprin-1 and Nesprin-2, which span the outer membrane and bind cytoplasmic actin (Padmakumar et al. 2005, Ding et al. 2007, Schmitt et al. 2007). Lamin-B1 and Lamin-C2 are located adjacent to the attachment plate on the inner membrane (Padmakumar et al. 2005, Schmitt et al. 2007).
Scherthan, H, Weich, S, Schwegler, H, Heyting, C, Härle, M, Cremer, T
Schmitt, J, Benavente, R, Hodzic, D, Höög, C, Stewart, CL, Alsheimer, M
Ding, X, Xu, R, Yu, J, Xu, T, Zhuang, Y, Han, M
Padmakumar, VC, Libotte, T, Lu, W, Zaim, H, Abraham, S, Noegel, AA, Gotzmann, J, Foisner, R, Karakesisoglou, I
© 2021 Reactome
