Reactome: A Curated Pathway Database

Removal of Spo11 and Resection of 5' Ends of DNA

Stable Identifier
R-MMU-912357
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
Locations in the PathwayBrowser
Summation

After cleaving DNA Spo11 remains covalently attached to the 5' ends. Spo11 is removed by cleavage of the DNA and release of Spo11:oligonucleotide complexes (Neale et al. 2005, Pan and Keeney 2009). In yeast, the Mre11:Rad50:Xrs2 complex is required for processing of double-strand breaks introduced by Spo11 (Cherry et al. 2007). The homologous Mre11:Rad50:Nbs1 complex from mouse has not been observed to localize to double-strand breaks made by Spo11 on autosomes. The enzymes responsible for removal of Spo11 and resection of the 3' ends remain unknown.

Literature References
Participants
Participant Of
Inferred From
Orthologous Events