Prdm9 Binds Recombination Hotspot Motifs in DNA

Stable Identifier
R-MMU-912383
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Prdm9 Binds Recombination Hotspot Motifs in DNA

The Prdm9 protein binds to sequences that are hotspots for recombination (Baudat et al. 2010, Myers et al. 2010). Prdm9 is homologous to methyltransferases that methylate histone H3 at lysine4 (H3K4) and has been shown to trimethylate H3K4 (Hayashi et al. 2005). In yeast and mice, H3K4 methylation marks recombination hotspots.

Literature References
PubMed ID Title Journal Year
20044538 Prdm9 controls activation of mammalian recombination hotspots

Parvanov, ED, Petkov, PM, Paigen, K

Science 2010
20044539 PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice

Baudat, F, Buard, J, Grey, C, Fledel-Alon, A, Ober, C, Przeworski, M, Coop, G, de Massy, B

Science 2010
19074312 A mouse speciation gene encodes a meiotic histone H3 methyltransferase

Mihola, O, Trachtulec, Z, Vlcek, C, Schimenti, JC, Forejt, J

Science 2009
16292313 A histone H3 methyltransferase controls epigenetic events required for meiotic prophase

Hayashi, K, Yoshida, K, Matsui, Y

Nature 2005
Participants
Input
Output
Orthologous Events
PRDM9 binds recombination hotspot motifs in DNA (Homo sapiens)
Authored
May, B  (2010-07-03)
Reviewed
Bolcun-Filas, E  (2011-02-25)
Cohen, PE  (2011-02-05)
Holloway, JK  (2011-02-05)
Lyndaker, A  (2011-02-25)
Schimenti, JC  (2011-02-05)
Strong, E  (2011-02-25)
Created
May, B  (2010-07-09)