The Prdm9 protein binds to sequences that are hotspots for recombination (Baudat et al. 2010, Myers et al. 2010). Prdm9 is homologous to methyltransferases that methylate histone H3 at lysine4 (H3K4) and has been shown to trimethylate H3K4 (Hayashi et al. 2005). In yeast and mice, H3K4 methylation marks recombination hotspots.
de Massy, B