Atr Phosphorylates Histone H2A.X at Unsynapsed Regions

Stable Identifier
R-MMU-912423
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Atr Phosphorylates Histone H2A.X at Unsynapsed Regions

The Atr kinase phosphorylates H2A.x at Serine 140 (Turner et al. 2004, Bellani et al. 2005, Mahadevaiah et al. 2008).

Literature References
PubMed ID Title Journal Year
15998665 SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes

Bellani, MA, Romanienko, PJ, Cairatti, DA, Camerini-Otero, RD

J Cell Sci 2005
15589157 BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation

Turner, JM, Aprelikova, O, Xu, X, Wang, R, Kim, S, Chandramouli, GV, Barrett, JC, Burgoyne, PS, Deng, CX

Curr Biol 2004
18663141 Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation

Mahadevaiah, SK, Bourc'his, D, de Rooij, DG, Bestor, TH, Turner, JM, Burgoyne, PS

J Cell Biol 2008
Participants
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Synaptonemal Complex:BRCA1:ATR [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created