Formation of Meiotic Heteroduplex

Stable Identifier
R-MMU-912431
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
Summation

Following double strand break (DSB) formation and strand resection, Rad51 and Dmc1 coat single-stranded 3' ends of DNA and catalyze the search for homology and strand invasion into the DNA duplex of the chromosomal homolog (Barlow et al. 1997). The invading strand displaces the original strand of the chromosomal homolog creating a D-loop structure. Other proteins in the complex are inferred from cytology (Barlow et al. 1997, Plug et al. 1997, Plug et al. 1998, Moens et al. 2002).

Literature References
PubMed ID Title Journal Year
9443891 Changes in protein composition of meiotic nodules during mammalian meiosis

Plug, AW, Peters, AH, Keegan, KS, Hoekstra, MF, de Boer, P, Ashley, T

J Cell Sci 1998
11950880 The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination

Moens, PB, Kolas, NK, Tarsounas, M, Marcon, E, Cohen, PE, Spyropoulos, B

J Cell Sci 2002
9311981 Distribution of the Rad51 recombinase in human and mouse spermatocytes

Barlow, AL, Benson, FE, West, SC, HultÚn, MA

EMBO J 1997
9398850 ATM and RPA in meiotic chromosome synapsis and recombination

Plug, AW, Peters, AH, Xu, Y, Keegan, KS, Hoekstra, MF, Baltimore, D, de Boer, P, Ashley, T

Nat Genet 1997
Participants
Orthologous Events
Authored
Reviewed