Synapsis

Stable Identifier
R-MMU-912506
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Synapsis
Initiation of recombination precedes and is required for synapsis. The synaptonemal complex forms when transverse filaments of Sycp1 link axial/lateral elements of sister chromatids to a central element comprising Syce1, Syce2, and other proteins (Allen et al. 1996, Liu et al. 1996, Kovalenko et al. 1996, Mahadevaiah et al. 2001, Crackower et al. 2003, de Vries et al. 2005, Costa et al. 2005, Hamer et al. 2006, Bolcun-Filas et al. 2007, Hamer et al. 2008, Bolcun-Filas et al. 2009, Prieto et al. 2009). The order of assembly is unknown.
Literature References
PubMed ID Title Journal Year
19557426 Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis

Prieto, I, Kouznetsova, A, Fütterer, A, Trachana, V, Leonardo, E, Alonso Guerrero, A, Cano Gamero, M, Pacios-Bras, C, Leh, H, Buckle, M, Garcia-Gallo, M, Kremer, L, Serrano, A, Roncal, F, Albar, JP, Barbero, JL, Martinez-A, C, van Wely, KH

Chromosoma 2009
8610150 Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes

Kovalenko, OV, Plug, AW, Haaf, T, Gonda, DK, Ashley, T, Ward, DC, Radding, CM, Golub, EI

Proc Natl Acad Sci U S A 1996
8660934 Localization of the N-terminus of SCP1 to the central element of the synaptonemal complex and evidence for direct interactions between the N-termini of SCP1 molecules organized head-to-head

Liu, JG, Yuan, L, Brundell, E, Björkroth, B, Daneholt, B, Höög, C

Exp Cell Res 1996
19247432 Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair

Bolcun-Filas, E, Hall, E, Speed, R, Taggart, M, Grey, C, de Massy, B, Benavente, R, Cooke, HJ

PLoS Genet 2009
18611960 Progression of meiotic recombination requires structural maturation of the central element of the synaptonemal complex

Hamer, G, Wang, H, Bolcun-Filas, E, Cooke, HJ, Benavente, R, Höög, C

J Cell Sci 2008
15937223 Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation

de Vries, FA, de Boer, E, van den Bosch, M, Baarends, WM, Ooms, M, Yuan, L, Liu, JG, van Zeeland, AA, Heyting, C, Pastink, A

Genes Dev 2005
11242108 Recombinational DNA double-strand breaks in mice precede synapsis

Mahadevaiah, SK, Turner, JM, Baudat, F, Rogakou, EP, de Boer, P, Blanco-Rodriguez, J, Jasin, M, Keeney, S, Bonner, WM, Burgoyne, PS

Nat Genet 2001
8601336 HSP70-2 is part of the synaptonemal complex in mouse and hamster spermatocytes

Allen, JW, Dix, DJ, Collins, BW, Merrick, BA, He, C, Selkirk, JK, Poorman-Allen, P, Dresser, ME, Eddy, EM

Chromosoma 1996
15944401 Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis

Costa, Y, Speed, R, Ollinger, R, Alsheimer, M, Semple, CA, Gautier, P, Maratou, K, Novak, I, Höög, C, Benavente, R, Cooke, HJ

J Cell Sci 2005
17339376 SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination

Bolcun-Filas, E, Costa, Y, Speed, R, Taggart, M, Benavente, R, de Rooij, DG, Cooke, HJ

J Cell Biol 2007
16968740 Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex

Hamer, G, Gell, K, Kouznetsova, A, Novak, I, Benavente, R, Höög, C

J Cell Sci 2006
12764197 Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis

Crackower, MA, Kolas, NK, Noguchi, J, Sarao, R, Kikuchi, K, Kaneko, H, Kobayashi, E, Kawai, Y, Kozieradzki, I, Landers, R, Mo, R, Hui, CC, Nieves, E, Cohen, PE, Osborne, LR, Wada, T, Kunieda, T, Moens, PB, Penninger, JM

Science 2003
21637789 A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility

Schramm, S, Fraune, J, Naumann, R, Hernandez-Hernandez, A, Höög, C, Cooke, HJ, Alsheimer, M, Benavente, R

PLoS Genet. 2011
Participants
Input
Output
Orthologous Events
Synapsis (Homo sapiens)
Authored
May, B  (2010-07-03)
Reviewed
Bolcun-Filas, E  (2011-02-25)
Cohen, PE  (2011-02-05)
Holloway, JK  (2011-02-05)
Lyndaker, A  (2011-02-25)
Schimenti, JC  (2011-02-05)
Strong, E  (2011-02-25)
Created
May, B  (2010-07-09)
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