Reactome | phospho-Stat3 [cytosol]

phospho-Stat3 [cytosol]

Stable Identifier

R-MMU-914048

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-Y705-STAT3, P42227

Locations in the PathwayBrowser for interactor IntAct:EBI-4566324

Expand all

External Reference Information

External Reference

UniProt:P42227 Stat3

Gene Names

Stat3, Aprf

Chain

initiator methionine:1, chain:2-770

Reference Genes

BioGPS Gene:20848 Stat3

ENSEMBL:ENSMUSG00000004040 Stat3

KEGG Gene (Mus musculus):20848 Stat3

Monarch:20848 Stat3

NCBI Gene:20848 Stat3

UCSC:P42227 Stat3

Reference Transcript

Other Identifiers

10391301

1426587_a_at

1460700_at

17269717

20848

4309728

4433360

4444418

4468798

4479961

4481009

4481594

4550236

4618361

4677664

4728349

4867037

4898482

4900043

4910817

4921230

4940799

4958931

5088448

5141613

5143533

5157405

5179940

5182064

5182147

5219551

5235738

5237856

5343169

5364019

5378195

5387158

5411533

5473808

5483912

5522241

99099_at

99100_at

A_51_P201480

A_52_P569499

A_55_P1991219

GE119376

GE33020

GE38473

GO:0003674

GO:0003677

GO:0003700

GO:0005575

GO:0005622

GO:0005634

GO:0006355

GO:0007165

GO:0008150

GO:0009058

GO:0034641

GO:0043226

ILMN_2589790

ILMN_2698046

ILMN_3096144

aa396029_s_at

mMC021060

mMR029005

u06922_s_at

Participates

as an output of

as a component of

as an input of

as a member of

Other forms of this molecule

phospho-Stat3 [nucleoplasm]

Stat3 [cytosol]

p-Y705-Stat3 [cytosol]

Stat3 [cytosol]

p(Y705)-Stat3 [nucleoplasm]

phospho-Stat3 [cytosol]

phospho-Stat3 [nucleoplasm]

phospho-Stat3 [cytosol]

phospho-Stat3 [nucleoplasm]

Inferred From

p-Y705-STAT3 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 705 (in Homo sapiens)

Coordinate

705

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_998825.1, NP_998824.1

ZINC - Substances

STAT3_MOUSE

ZINC target

P42227

Ensembl

ENSMUSP00000090342, ENSMUSP00000120152, ENSMUST00000092671, ENSMUSP00000099403, ENSMUST00000127638, ENSMUST00000103114, ENSMUSG00000004040

PRO

P42227

MGI

103038

ZINC - Predictions - Purchasable

STAT3_MOUSE

PDB

4E68, 4ZIA, 1BG1, 3CWG

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40189 IL6ST	2	IL6ST [plasma membrane] (R-HSA-448453) p-Y-IL6ST [plasma membrane] (R-HSA-8950439)	0.656	4
UniProt:Q00175	3	Pgr [cytosol] (R-MMU-8948964) Pgr [nucleoplasm] (R-MMU-4341032) Pgr [nucleoplasm] (R-MMU-3008952)	0.649	4
UniProt:O54784 Dapk3	1	Death-associated protein kinase 3 [cytosol] (R-MMU-418772)	0.645	8
IntAct:EBI-6398447 IL17F			0.643	3
IntAct:EBI-4566324 IL17			0.643	4
UniProt:Foxp3 ENSMUSG00000039521			0.643	3
UniProt:P48025 Syk	8	phospho-Syk [cytosol] (R-MMU-9705732) p-Syk [cytosol] (R-MMU-9676057) phospho-Syk [plasma membrane] (R-MMU-429432) Syk [cytosol] (R-MMU-442293) p-Y348,Y352,Y525,Y526-Syk [cytosol] (R-MMU-5621123) phospho-Syk [cytosol] (R-MMU-983586) phospho-Syk [cytosol] (R-MMU-437953) Syk [cytosol] (R-MMU-58268)	0.611	5
UniProt:P42227 Stat3	11	phospho-Stat3 [cytosol] (R-MMU-914048) phospho-Stat3 [nucleoplasm] (R-MMU-1112554) Stat3 [cytosol] (R-MMU-539044) p-Y705-Stat3 [cytosol] (R-MMU-914034) Stat3 [cytosol] (R-MMU-914084) p(Y705)-Stat3 [nucleoplasm] (R-MMU-2730582) phospho-Stat3 [cytosol] (R-MMU-8983130) phospho-Stat3 [nucleoplasm] (R-MMU-9027589) phospho-Stat3 [cytosol] (R-MMU-539048) phospho-Stat3 [cytosol] (R-MMU-8982823) phospho-Stat3 [nucleoplasm] (R-MMU-8983188)	0.609	3
UniProt:P23927	1	Cryab [nucleoplasm] (R-MMU-6806336)	0.608	3
UniProt:P70424	10	phospho-Erbb2 [plasma membrane] (R-MMU-8863836) phospho-Erbb2 [plasma membrane] (R-MMU-8863841) phospho-Erbb2 [plasma membrane] (R-MMU-8864084) phospho-Erbb2 [plasma membrane] (R-MMU-8864090) phospho-Erbb2 [plasma membrane] (R-MMU-1810438) Erbb2 [plasma membrane] (R-MMU-372889) phospho-Erbb2 [plasma membrane] (R-MMU-1963569) phospho-Erbb2 [plasma membrane] (R-MMU-8864081) phospho-Erbb2 [plasma membrane] (R-MMU-8864079) phospho-Erbb2 [plasma membrane] (R-MMU-1248698)	0.537	4
UniProt:P30084 ECHS1	1	ECHS1 [mitochondrial matrix] (R-HSA-54125)	0.524	3
UniProt:Q64261	3	Cdk6 [nucleoplasm] (R-MMU-141283) Cdk6 [cytosol] (R-MMU-68336) phospho-Cdk6 [nucleoplasm] (R-MMU-69628)	0.499	3
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.463	3

Cite Us!