Reactome | Tfrc [plasma membrane]

Tfrc [plasma membrane]

Stable Identifier

R-MMU-917983

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

TFRC(1-760), Q62351

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - AP-2 directly binds some endocytic cargo (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Mus musculus)
        
        holoTF:TFRC dimer [plasma membrane] (Mus musculus)
        
        TFRC dimer [plasma membrane] (Mus musculus)
        
        Tfrc [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q62351

Gene Names

Tfrc

Reference Genes

BioGPS Gene:22042 Tfrc

ENSEMBL:ENSMUSG00000022797

ENSEMBL:ENSMUSG00000022797.17 Tfrc

KEGG Gene (Mus musculus):22042 Tfrc

Monarch:22042 Tfrc

NCBI Gene:22042 Tfrc

UCSC:Q62351 Tfrc

Reference Transcript

Other Identifiers

103957_at

103958_g_at

10435075

139035_at

1422966_a_at

1422967_a_at

1452661_at

162738_at

17324835

22042

4466844

4596385

4640634

4688178

4689153

4715360

4766853

4822528

4829397

4937888

4975614

5064989

5081556

5092915

5156104

5198204

5237096

5342826

5479858

5541164

5575480

5584282

AFFX-TransRecMur/X57349_3_at

AFFX-TransRecMur/X57349_5_at

AFFX-TransRecMur/X57349_M_at

A_51_P167876

A_52_P228236

A_65_P06446

GE38144

GO:0001666

GO:0001934

GO:0002376

GO:0003723

GO:0003725

GO:0004998

GO:0005215

GO:0005381

GO:0005515

GO:0005576

GO:0005615

GO:0005768

GO:0005769

GO:0005886

GO:0005905

GO:0006310

GO:0006826

GO:0006879

GO:0006897

GO:0006953

GO:0006954

GO:0007005

GO:0007155

GO:0007584

GO:0009897

GO:0009986

GO:0010008

GO:0010033

GO:0010035

GO:0010039

GO:0010042

GO:0010628

GO:0010637

GO:0012501

GO:0016020

GO:0016192

GO:0016323

GO:0019901

GO:0023052

GO:0030154

GO:0030316

GO:0030544

GO:0030890

GO:0031334

GO:0031410

GO:0031623

GO:0031668

GO:0032526

GO:0033138

GO:0033572

GO:0034755

GO:0035556

GO:0036211

GO:0038024

GO:0042102

GO:0042470

GO:0042802

GO:0042803

GO:0043066

GO:0043123

GO:0043226

GO:0043231

GO:0044877

GO:0045780

GO:0045830

GO:0046688

GO:0048471

GO:0048856

GO:0051087

GO:0055037

GO:0055038

GO:0055065

GO:0055085

GO:0065003

GO:0070062

GO:0071281

GO:0071466

GO:1900182

GO:1990712

GO:1990830

ILMN_2619848

ILMN_2860804

Msa.2507.0_s_at

mMC013763

Participates

as a candidate of

as a component of

TFRC dimer [plasma membrane] (Mus musculus)

Other forms of this molecule

Tfrc [clathrin-coated endocytic vesicle membrane]

Tfrc [Golgi membrane]

Tfrc [cytoplasmic vesicle membrane]

Tfrc [endosome membrane]

Inferred From

TFRC(1-760) [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_006522062.1, NP_035768.1

Ensembl

ENSMUST00000023486, ENSMUSP00000023486, ENSMUSG00000022797

PRO

Q62351

MGI

98822

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