Reactome | TANK [cytosol]

TANK [cytosol]

Stable Identifier

R-MMU-933407

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

P70347

Locations in the PathwayBrowser for interactor UniProt:Q9WUN2

Expand all

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Mus musculus)
        
        TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 (Mus musculus)
        
        TANK [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P70347

Reference Genes

BioGPS Gene:21353

ENSEMBL:ENSMUSG00000064289

ENSEMBL:ENSMUSG00000064289.16

KEGG Gene (Mus musculus):21353

Monarch:21353

NCBI Gene:21353

UCSC:P70347

Reference Transcript

Other Identifiers

103328_at

10472289

1421640_a_at

17371101

21353

4359120

4490246

4532600

4654838

4679741

4764981

4803151

4860079

4894919

4924955

4940129

4983259

5074842

5173303

5430384

5443353

5465410

5590861

A_51_P377547

A_55_P2109827

GE36172

GO:0003824

GO:0004843

GO:0005515

GO:0005737

GO:0005829

GO:0006974

GO:0007249

GO:0016787

GO:0023052

GO:0031625

GO:0032481

GO:0032991

GO:0035800

GO:0036211

GO:0043124

GO:0046872

GO:0060090

GO:0071347

GO:0071356

GO:0071479

GO:0098772

GO:0140096

GO:1903003

GO:2000158

ILMN_1220799

ILMN_2660438

ILMN_2734028

mMC007537

u51907_s_at

Participates

as an input of

TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 (Mus musculus)

as a component of

TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)

Other forms of this molecule

K63polyUb-TANK [cytosol]

Inferred From

TANK [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006499151.1, XP_017172402.1, NP_035659.1, NP_001157544.1

Ensembl

ENSMUST00000078074, ENSMUSG00000064289, ENSMUSP00000077219, ENSMUSP00000108120, ENSMUST00000112501

PRO

P70347

MGI

107676

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9WUN2 Tbk1	5	phospho-pS-172,K48polyUb-TBK1 [cytosol] (R-MMU-3249397) phospho-Q9WUN2 [cytosol] (R-MMU-9008705) K63polyUb-K30,K401-TBK1 [cytosol] (R-MMU-9730430) p-S172-Tbk1 [cytosol] (R-MMU-1810465) Tbk1 [cytosol] (R-MMU-1810477)	0.75	7

Cite Us!