Inhibition of Rig-I signaling by Atg5-Atg12 conjugate

Stable Identifier
R-MMU-936387
Type
Reaction
Species
Mus musculus
Compartment
Summation

Autophagy protein 5 (ATG5) and autophagy-related protein 12 (ATG12) conjugate negatively regulates the type I IFN production pathway by directly associating with DDX58/IFIH1 and MAVS through the caspase recruitment domains (CARDs). The ATG5-ATG12 conjugate intercalates between the CARDs of DDX58/IFIH1 and MAVS and inhibits signal transmission, resulting in suppression of type I IFN production and innate antiviral immune responses.

Literature References
PubMed ID Title Journal Year
17709747 The Atg5 Atg12 conjugate associates with innate antiviral immune responses Proc Natl Acad Sci U S A 2007
Participants
Orthologous Events