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Traf6 [plasma membrane]
Stable Identifier
R-MMU-936980
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
K63polyUb-TRAF6, P70196
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
IRAK2 mediated activation of TAK1 complex (Mus musculus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Traf6 [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:P70196 Traf6
Gene Names
Traf6
Chain
chain:1-530
Reference Genes
BioGPS Gene:22034 Traf6
ENSEMBL:ENSMUSG00000027164.9 Traf6
KEGG Gene (Mus musculus):22034 Traf6
Monarch:22034 Traf6
NCBI Gene:22034 Traf6
UCSC:P70196 Traf6
Reference Transcript
RefSeq:NM_009424.3 Traf6
RefSeq:NM_001303273.1 Traf6
Other Identifiers
104189_at
104190_at
10474112
132117_at
1421376_at
1421377_at
1435350_at
1443288_at
1446977_at
17373644
22034
4385088
4388194
4468070
4469529
4507002
4545262
4616519
4776963
4900353
4901148
4914408
5104652
5218925
5300326
5466380
98874_at
A_51_P495259
A_52_P510215
A_52_P625495
A_66_P117448
D84655_s_at
GE33842
GO:0000045
GO:0000122
GO:0000209
GO:0001503
GO:0001701
GO:0001843
GO:0002376
GO:0002637
GO:0002726
GO:0002753
GO:0003824
GO:0004842
GO:0005164
GO:0005515
GO:0005634
GO:0005737
GO:0005811
GO:0005829
GO:0005886
GO:0005938
GO:0006351
GO:0006355
GO:0006914
GO:0006955
GO:0006974
GO:0007155
GO:0007165
GO:0007249
GO:0007254
GO:0008270
GO:0009887
GO:0009898
GO:0012501
GO:0016567
GO:0016740
GO:0019221
GO:0019886
GO:0023052
GO:0030154
GO:0030316
GO:0031234
GO:0031624
GO:0031625
GO:0031663
GO:0031666
GO:0032481
GO:0032735
GO:0032743
GO:0032755
GO:0032813
GO:0032991
GO:0033209
GO:0034142
GO:0034450
GO:0035556
GO:0035631
GO:0036211
GO:0038061
GO:0038172
GO:0038173
GO:0042088
GO:0042102
GO:0042475
GO:0042802
GO:0042826
GO:0042981
GO:0043011
GO:0043122
GO:0043123
GO:0043226
GO:0043422
GO:0045087
GO:0045453
GO:0045672
GO:0045892
GO:0045944
GO:0046849
GO:0046872
GO:0048468
GO:0048471
GO:0048661
GO:0048856
GO:0050852
GO:0051092
GO:0051865
GO:0061630
GO:0070498
GO:0070534
GO:0070555
GO:0071222
GO:0071345
GO:0097400
GO:0098542
GO:0140096
GO:0140374
GO:1904996
ILMN_1239417
ILMN_1259162
ILMN_2427560
ILMN_2960750
aa118698_at
aa118698_g_at
mMC003331
mMC004649
mMR028982
Participates
as a component of
p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Mus musculus)
Other forms of this molecule
Traf6 [cytosol]
Traf6 [cytosol]
Traf6 [cytosol]
Traf6 [endosome membrane]
Traf6 [endosome membrane]
Traf6 [plasma membrane]
Traf6 [cytosol]
Traf6 [cytosol]
Inferred From
K63polyUb-TRAF6 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [plasma membrane]) at 124 (in Homo sapiens)
Coordinate
124
Modification
K63polyUb [plasma membrane]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_033450.2
,
NP_001290202.1
Ensembl
ENSMUSG00000027164
,
ENSMUST00000004949
,
ENSMUSP00000004949
PRO
P70196
MGI
108072
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62991 UBIQ
0.835
5
UniProt:Q9QZH6
2
Ecsit [mitochondrial inner membrane]
(R-MMU-5689047)
Ecsit [cytosol]
(R-MMU-168064)
0.729
5
UniProt:P22366
1
Myd88 [cytosol]
(R-MMU-166059)
0.623
4
UniProt:Q61084
1
MAP3K3 [cytosol]
(R-MMU-507725)
0.589
5
UniProt:Q8C0E5 Q8C0E5
0.581
3
UniProt:Q8K4B2
1
IRAK3 [cytosol]
(R-MMU-166103)
0.547
3
UniProt:Q8N7N6 CIKS
0.547
4
UniProt:Q62227
1
Nr0b2 [nucleoplasm]
(R-MMU-376312)
0.537
5
UniProt:P17879
4
HSPA1A [nucleoplasm]
(R-MMU-6792605)
HSPA1A [extracellular region]
(R-MMU-6805872)
HSPA1A [ficolin-1-rich granule lumen]
(R-MMU-6801496)
HSPA1A [cytosol]
(R-MMU-6792602)
0.524
3
UniProt:Q9EQY0
2
phospho-p-S724-ERN1 [endoplasmic reticulum membrane]
(R-MMU-381029)
ERN1 [endoplasmic reticulum membrane]
(R-MMU-381076)
0.524
6
UniProt:Q793I8
2
Tifa [cytosol]
(R-MMU-451582)
phospho-Tifa [cytosol]
(R-MMU-9645512)
0.508
2
UniProt:O35305
1
TNFRSF11A [plasma membrane]
(R-MMU-5668756)
0.508
2
UniProt:P27512
1
Cd40 [plasma membrane]
(R-MMU-198117)
0.508
2
UniProt:Q96CG3 TIFA
2
TIFA [cytosol]
(R-HSA-451582)
p-T9-TIFA [cytosol]
(R-HSA-9645512)
0.499
4
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